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Low skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis

التفاصيل البيبلوغرافية
العنوان: Low skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis
المؤلفون: Nadia M. Anabtawi, Monica Sai Pasala, Alyssa A. Grimshaw, Prakash Kharel, Susan Bal, Kelly Godby, Ashmita Siwakoti, Thomas W. Buford, Smita Bhatia, Luciano J. Costa, Grant R. Williams, Smith Giri
المصدر: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1084-1093 (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Diseases of the musculoskeletal system
LCC:Human anatomy
مصطلحات موضوعية: Adverse outcomes, Muscle mass, Prognostication, Sarcopenia, Toxicities, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
الوصف: Abstract Background Low skeletal muscle mass (LSMM) and/or, function associated with an increased risk of treatment‐related toxicities and inferior overall survival (OS) among adults with solid malignancies. However, the association between LSMM and treatment‐related toxicities among adults with haematologic malignancies remains unclear. Methods Using a pre‐published protocol (CRD42020197814), we searched seven bibliographic databases from inception to 08/2021 for studies reporting the impact of LSMM among adults ≥18 years with a known haematologic malignancy. The primary outcome of interest was OS, and secondary outcomes included progression free survival (PFS) and non‐relapse mortality (NRM). These effect sizes were quantified in terms of hazards ratio (HR) along with 95% confidence interval (CI) and pooled across studies using a DerSimonian–Laird random‐effects model. Heterogeneity was assessed using the Cochran's Q and the I2 statistic. All hypothesis testing was two‐sided with an alpha of 0.05. Results Of 3791 studies screened, we identified 20 studies involving 3468 patients with a mean age of 60 years; 44% were female and the most common malignancy was diffuse large B‐cell lymphoma (42%). Most studies measured muscle mass using single slice computed tomography imaging at the L3 level. The presence of LSMM was associated with worse OS (pooled HR = 1.81, 95% CI = 1.48–2.22, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2190-6009
2190-5991
Relation: https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009
DOI: 10.1002/jcsm.13446
URL الوصول: https://doaj.org/article/af902c648c5746f4abe5b7abfad8f3d2
رقم الأكسشن: edsdoj.f902c648c5746f4abe5b7abfad8f3d2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21906009
21905991
DOI:10.1002/jcsm.13446