دورية أكاديمية
Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice
| العنوان: | Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice |
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| المؤلفون: | Maki Kitai, Noboru Fukuda, Takahiro Ueno, Morito Endo, Takashi Maruyama, Masanori Abe, Kazuyoshi Okada, Masayoshi Soma, Koichi Matsumoto |
| المصدر: | Journal of Pharmacological Sciences, Vol 134, Iss 1, Pp 29-36 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Syk, Lupus nephritis, Fc receptor, 3BP2, p38MAP kinase, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP kinase signalings in mice. NZB/W F1 mice, a model of lupus nephritis, received a Syk inhibitor R406. Western blotting and immunohistochemistry revealed that R406 treatment significantly delayed the appearance of proteinuria, histologically improved their glomerulosclerosis and inhibited the increased the expression of MCP-1 and TGF-β1 mRNAs and the nephrin and podocin proteins in the kidney. The treatment suppressed the phosphorylation of 3BP2 in white blood cells from the spleen and significantly inhibited the phosphorylation of p38MAPK in the kidney but did not affect expression of neonatal Fc receptor. These findings indicate the important roles and mechanisms of Fcγ receptors I and III in the development of autoimmune glomerulonephritis and suggest the possible application of Syk inhibitors as novel medicines for the glomerulonephritis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1347-8613 07428472 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1347861317300415; https://doaj.org/toc/1347-8613 |
| DOI: | 10.1016/j.jphs.2017.02.015 |
| URL الوصول: | https://doaj.org/article/fa7cb2e074284727a54160abe18929c0 |
| رقم الأكسشن: | edsdoj.fa7cb2e074284727a54160abe18929c0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13478613 07428472 |
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| DOI: | 10.1016/j.jphs.2017.02.015 |