دورية أكاديمية
Human leukocyte antigen association with anti-SARS-CoV-2 spike protein antibody seroconversion in renal allograft recipients - An observational study
| العنوان: | Human leukocyte antigen association with anti-SARS-CoV-2 spike protein antibody seroconversion in renal allograft recipients - An observational study |
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| المؤلفون: | Brijesh Yadav, Narayan Prasad, Deependra Yadav, Ankita Singh, Sonam Gautam, Ravishankar Kushwaha, Manas Ranjan Patel, Dharmendra Bhadauria, Manas Ranjan Behera, Monika Yachha, Anupama Kaul |
| المصدر: | Indian Journal of Transplantation, Vol 16, Iss 4, Pp 397-404 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | anti- sars-cov-2 antibody, human leucocyte antigen, home quarantine, seroconversion, Surgery, RD1-811 |
| الوصف: | Cellular and humoral responses are required for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) eradication. Antigen-presenting cells load SARS-CoV-2 peptides on human leukocyte antigen (HLA) with different avidities and present to T- and B-cells for imposing humoral and cellular responses. Due to immunosuppression, renal transplant recipient (RTR) patients are speculated to poorly form the antibody against the SARS-CoV-2. Therefore, determining the association of specific HLA alleles with anti-SARS-CoV-2 spike protein antibody formation will be helpful in managing the RTR having specific HLA alleles from SARS-CoV-2 infection and vaccination. Materials and Methods: In this study, anti-SARS-CoV-2 spike protein antibody in 161 RTRs was determined by the chemiluminescent microparticle immunoassay methods, and HLA alleles were determined by the polymerase chain reaction-single-strand oligonucleotide methods and analyzed to study the HLA allele association with anti-SARS-CoV-2 spike protein-specific humoral response and severity of COVID-19 symptoms in recently SARS-CoV-2-infected RTRs. Results: The anti-SARS-CoV-2 spike protein specific antibody seroconversion rate in RTRs was 90.06% with a median titer of 751.80 AU/ml. The HLA class I alleles, A*11 in 22.1%, A*24 in 21.37%, A*33 in 20.68%, HLA B*15 in 11%, B*07 in 8.27%, HLA-C*30 in 20.93%, C*70 in 23.25% and HLA Class II alleles, DRB1*07 in 18.62%, DRB1*04 in 13.8%, HLA-DRB1*10 in 14.48%, HLA-DQA1*50 in 32.55% of RTRs were associated with the seroconversion. The mean SARS-CoV-2 clearance time was 18.25 ± 8.14 days. Conclusions: RTRs with SARS-CoV-2 infection developed a robust seroconversion rate of 90.0% and different alleles of HLA-B, DRB1, and DQA1 were significantly associated with the seroconversion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2212-0017 2212-0025 |
| Relation: | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2022;volume=16;issue=4;spage=397;epage=404;aulast=Yadav; https://doaj.org/toc/2212-0017; https://doaj.org/toc/2212-0025 |
| DOI: | 10.4103/ijot.ijot_28_22 |
| URL الوصول: | https://doaj.org/article/fb3577e4179a429baf6a4aeab8df8649 |
| رقم الأكسشن: | edsdoj.fb3577e4179a429baf6a4aeab8df8649 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22120017 22120025 |
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| DOI: | 10.4103/ijot.ijot_28_22 |