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Maternal dietary methionine restriction alters hepatic expression of one-carbon metabolism and epigenetic mechanism genes in the ducklings

التفاصيل البيبلوغرافية
العنوان: Maternal dietary methionine restriction alters hepatic expression of one-carbon metabolism and epigenetic mechanism genes in the ducklings
المؤلفون: Aurélie Sécula, Lisa E. Bluy, Hervé Chapuis, Agnès Bonnet, Anne Collin, Laure Gress, Alexis Cornuez, Xavier Martin, Loys Bodin, Cécile M. D. Bonnefont, Mireille Morisson
المصدر: BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Biotechnology
LCC:Genetics
مصطلحات موضوعية: Duck, Methyl donor, Nutritional programming, Differentially expressed genes, Avian, Biotechnology, TP248.13-248.65, Genetics, QH426-470
الوصف: Abstract Background Embryonic and fetal development is very susceptible to the availability of nutrients that can interfere with the setting of epigenomes, thus modifying the main metabolic pathways and impacting the health and phenotypes of the future individual. We have previously reported that a 38% reduction of the methyl donor methionine in the diet of 30 female ducks reduced the body weight of their 180 mule ducklings compared to that of 190 ducklings from 30 control females. The maternal methionine-restricted diet also altered plasmatic parameters in 30 of their ducklings when compared to that of 30 ducklings from the control group. Thus, their plasma glucose and triglyceride concentrations were higher while their free fatty acid level and alanine transaminase activity were decreased. Moreover, the hepatic transcript level of 16 genes involved in pathways related to energy metabolism was significantly different between the two groups of ducklings. In the present work, we continued studying the liver of these newly hatched ducklings to explore the impact of the maternal dietary methionine restriction on the hepatic transcript level of 70 genes mostly involved in one-carbon metabolism and epigenetic mechanisms. Results Among the 12 genes (SHMT1, GART, ATIC, FTCD, MSRA, CBS, CTH, AHCYL1, HSBP1, DNMT3, HDAC9 and EZH2) identified as differentially expressed between the two maternal diet groups (p-value
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2164
Relation: https://doaj.org/toc/1471-2164
DOI: 10.1186/s12864-022-09066-7
URL الوصول: https://doaj.org/article/afb39a7aee43494f9a8d15f0e3ae1d25
رقم الأكسشن: edsdoj.fb39a7aee43494f9a8d15f0e3ae1d25
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14712164
DOI:10.1186/s12864-022-09066-7