دورية أكاديمية
MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia
| العنوان: | MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia |
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| المؤلفون: | Martina Del Gaizo, Ilaria Sergio, Sara Lazzari, Samantha Cialfi, Maria Pelullo, Isabella Screpanti, Maria Pia Felli |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 2, p 829 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microRNA, Notch, Natural Killer cells, T and regulatory T cells, MDSC, Acute lymphoblastic leukaemia, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/2/829; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23020829 |
| URL الوصول: | https://doaj.org/article/fb9573cbecd0466c81eb2e42d6fe1a49 |
| رقم الأكسشن: | edsdoj.fb9573cbecd0466c81eb2e42d6fe1a49 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23020829 |