دورية أكاديمية
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
| العنوان: | Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals |
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| المؤلفون: | Josefina Gómez-Garduño, Renato León-Rodríguez, Radamés Alemón-Medina, Beatriz E. Pérez-Guillé, Rosa E. Soriano-Rosales, Ailema González-Ortiz, Juan L. Chávez-Pacheco, Edelmira Solorio-López, Paola Fernandez-Pérez, Liliana Rivera-Espinosa |
| المصدر: | Dose-Response, Vol 20 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Phytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce plasma concentration of cyclosporine, simvastatin, celiprolol, midazolam, saquinavir, buspirone, everolimus, nadolol, tamoxifen, alprazolam, verapamil, quazepam, digoxin, fexofenadine, theophylline, indinavir, clopidogrel. Anthocyanins, flavonols, flavones, flavanones, flavonoid glycosides, stilbenes, diferuloylmethanes, catechin, hyperforin, alkaloids, terpenes, tannins and protoalkaloids increase of plasma concentration of buspirone, losartan, diltiazem, felodipine, midazolam, cyclosporine, triazolam, verapamil, carbamazepine, diltiazem, aripiprazole, tamoxifen, doxorubicin, paclitaxel, nicardipine. Interactions between Pchs and drugs affect the gene expression and enzymatic activity of CYP3A and P-gp transporter, which has an impact on their bioavailability; such that co-administration of drugs with food, beverages and food supplements can cause a subtherapeutic effect or overdose. Therefore, it is important for the clinician to consider these interactions to obtain a better therapeutic effect. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-3258 15593258 |
| Relation: | https://doaj.org/toc/1559-3258 |
| DOI: | 10.1177/15593258221120485 |
| URL الوصول: | https://doaj.org/article/fcc47119413b4b4fb547cb754a073e81 |
| رقم الأكسشن: | edsdoj.fcc47119413b4b4fb547cb754a073e81 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15593258 |
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| DOI: | 10.1177/15593258221120485 |