دورية أكاديمية
Pathogenesis and Therapy of Coagulation Disorders in Severe Acute Pancreatitis
| العنوان: | Pathogenesis and Therapy of Coagulation Disorders in Severe Acute Pancreatitis |
|---|---|
| المؤلفون: | Gui M, Zhao B, Huang J, Chen E, Qu H, Mao E |
| المصدر: | Journal of Inflammation Research, Vol Volume 16, Pp 57-67 (2023) |
| بيانات النشر: | Dove Medical Press, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pathology LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | coagulation, acute pancreatitis, endothelial cells，complement, anticoagulant therapy, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Menglu Gui,1,* Bing Zhao,1,* Jun Huang,2,* Erzhen Chen,1 Hongping Qu,3 Enqiang Mao1 1Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enqiang Mao, Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Huangpu District, Shanghai, People’s Republic of China, Tel +86 13501747906, Email maoeq@yeah.netAbstract: Ischemia superimposed upon pancreatic edema leads to acute necrotizing pancreatitis. One possible mechanism contributing to ischemia is intravascular thrombogenesis since fibrin deposits have been detected in pancreatic capillaries by electron microscope. Current experimental and clinical data provided compelling evidence that the disorders in the blood coagulation system play a critical role in the pathogenesis of severe acute pancreatitis (SAP). This leads to microcirculatory failure of intra- and extrapancreatic organs and multiple organ failure and increases the case fatality rate. However, the mechanism of coagulopathy underlying SAP is not yet clear, although some anticoagulant drugs have entered clinical practice showing improvement in prognosis. Thus, enhanced understanding of the process might improve the treatment strategies with safety and high efficacy. Herein, the pathogenesis of the coagulation system of SAP was reviewed with a focus on the coagulation pathway, intercellular interactions, and complement system, thereby illustrating some anticoagulant therapies and potential therapeutic targets.Keywords: coagulation, acute pancreatitis, endothelial cells, complement, anticoagulant therapy |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1178-7031 |
| Relation: | https://www.dovepress.com/pathogenesis-and-therapy-of-coagulation-disorders-in-severe-acute-panc-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031 |
| URL الوصول: | https://doaj.org/article/fde8f6912809461a9c6549a60cc08ca4 |
| رقم الأكسشن: | edsdoj.fde8f6912809461a9c6549a60cc08ca4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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