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Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

التفاصيل البيبلوغرافية
العنوان: Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies
المؤلفون: Shweta Paroha, Ravindra Dhar Dubey, Subrata Mallick
المصدر: Química Nova, Vol 37, Iss 1, Pp 81-84 (2014)
بيانات النشر: Sociedade Brasileira de Química, 2014.
سنة النشر: 2014
المجموعة: LCC:Chemistry
مصطلحات موضوعية: naproxen, calcium carbonate, in vitro dissolution, Chemistry, QD1-999
الوصف: Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
Spanish; Castilian
Portuguese
تدمد: 1678-7064
0100-4042
Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100015&lng=en&tlng=en; https://doaj.org/toc/1678-7064
DOI: 10.1590/S0100-40422014000100015
URL الوصول: https://doaj.org/article/fe718a185afe4cbc9b2e839c7bdfb653
رقم الأكسشن: edsdoj.fe718a185afe4cbc9b2e839c7bdfb653
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16787064
01004042
DOI:10.1590/S0100-40422014000100015