كتاب
Probing Protein Interactions with Stapled Peptides: Myc Family and Insulin Receptor.
| العنوان: | Probing Protein Interactions with Stapled Peptides: Myc Family and Insulin Receptor. |
|---|---|
| المؤلفون: | Liang, Rebecca Yue. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Chemistry, Biology |
| الوصف: | One of the most exciting frontiers of expanding pharmacopeia to combat currently untreatable diseases is achieving specifically and potently disruption of unwanted protein-protein interactions where traditional small molecule drugs tend to fall short. Our laboratory has developed the methodology of peptide stapling and pioneered successful applications in multiple disease models since its induction over a decade ago. One common feature of past applications is the use of a single stapled peptide in helical form, derived from the natural binding interface of target proteins. This dissertation ventures into protein interactions that involve multiple components and sites and explores the extended use of stapled peptides in these volatile settings. |
| Original Identifier: | ocn870922996 (DASH)11169826 |
| نوع الوثيقة: | Book |
| اللغة: | English |
| حقوق: | This record is part of the Harvard Library Bibliographic Dataset, which is provided by the Harvard Library under its Bibliographic Dataset Use Terms and includes data made available by, among others, OCLC Online Computer Library Center, Inc. and the Library of Congress. |
| Degree: | Ph.D., Harvard University, 2013. |
| رقم الأكسشن: | edshlc.013940644.1 |
| قاعدة البيانات: | Harvard Library Bibliographic Dataset |
| الوصف غير متاح. |