مورد إلكتروني
The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones.
| العنوان: | The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones. |
|---|---|
| المصدر: | The Journal of clinical endocrinology and metabolism, 80 (3 |
| بيانات النشر: | 1995-03 |
| تفاصيل مُضافة: | Elnagar, B Eltom, M Karlsson, F A Ermans, André Marie Gebre-Medhin, M Bourdoux, Pierre |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The prevention of iodine deficiency is still a worldwide concern. This study, conducted in Soja in western Sudan, was carried out to evaluate the effects of a dose of iodized oil sufficient enough to give maximum protection against goiter and provide an acceptable iodine supply without side-effects over a sufficiently long period of time. Adult goitrous subjects (n = 117) were randomly assigned to three groups, A, B, and C, and received a single oral dose of 200, 400, or 800 mg iodine, respectively. Urine and blood samples were collected at the start of the study and monitored for 1 yr. In the 3 groups, mean serum T4 and median urinary iodine and serum TSH values were restored to reference limits, and these were maintained for about 1 yr. In each treatment group, about two thirds of the subjects displayed a reduction in goiter size, and the 400- and 800-mg doses were not more efficient than the 200-mg dose to accomplish normalization of thyroid hormone values. A temporary rise in TSH was noted 1 week after iodine administration in 1, 3, and 10 subjects, respectively, and 1, 0, and 3 subjects showed biochemical signs of thyrotoxicosis during the year after treatment with the 3 different doses. The data indicate that oral administration of 200 mg iodine is effective and acceptable for treating iodine deficiency in adults for 1 yr. Because of the risks of side-effects and the shortage of medical resources, higher doses are not recommended. Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Epidémiologie, Chimie pharmaceutique, Endocrinologie, Obstétrique, Sciences bio-médicales et agricoles, Administration, Oral, Adolescent, Adult, Child, Child, Preschool, Dose-Response Relationship, Drug, Female, Goiter -- drug therapy, Humans, Infant, Infant, Newborn, Iodine -- deficiency -- urine, Iodized Oil -- administration & dosage -- adverse effects, Male, Middle Aged, Thyroid Hormones -- blood, Thyrotropin -- blood, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/123276 uri/info:doi/10.1210/jc.80.3.891 uri/info:pmid/7883848 uri/info:scp/0028968460 803507501 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn803507501 |
| قاعدة البيانات: | OAIster |
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