مورد إلكتروني
Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells.
| العنوان: | Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells. |
|---|---|
| المصدر: | Department of Microbiology and Immunology Faculty Papers |
| بيانات النشر: | Jefferson Digital Commons 2015-11-10T08:00:00Z |
| تفاصيل مُضافة: | Smith, Corinne J Caldeira-Dantas, Sofia Turula, Holly Snyder, Christopher M. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Cytomegalovirus (CMV) is a herpesvirus that persists for life and maintains extremely large numbers of T cells with select specificities in circulation. However, it is unknown how viral persistence impacts T cell populations in mucosal sites. We found that many murine (M)CMV-specific CD8s in mucosal tissues became resident memory T cells (TRM). These cells adopted an intraepithelial localization in the salivary gland that correlated with, but did not depend on, expression of the integrin CD103. MCMV-specific TRM cells formed early after infection, and spleen-localized cells had reduced capacities to become TRM at late times. Surprisingly, however, small numbers of new TRM cells were formed from the circulating pool throughout infection, favoring populations maintained at high levels in the blood and shifting the immunodominance within the TRM populations over time. These data show that mucosal TRM populations can be dynamically maintained by a persistent infection. |
| مصطلحات الفهرس: | Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University; animal cell; animal experiment; animal model; animal tissue; antigen expression; Article; CD8+ T lymphocyte; cellular distribution; controlled study; Cytomegalovirus; cytomegalovirus infection; female; lymphocyte differentiation; memory T lymphocyte; mouse; mucosal immunity; nonhuman; priority journal; salivary gland; steady state; T lymphocyte subpopulation; upregulation; virus replication, Medical Immunology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/4.0 |
| ملاحظة: | application/pdf |
| أرقام أخرى: | TVJ oai:jdc.jefferson.edu:mifp-1075 933588048 |
| المصدر المساهم: | THOMAS JEFFERSON UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.ocn933588048 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |