مورد إلكتروني
Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways
| العنوان: | Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways |
|---|---|
| عناروين إضافية: | Chelidonin a Homochelidonin indukují buněčnou smrt prostřednictvím drah checkpoint a MAP kináz |
| المؤلفون: | Havelek, Radim, Seifrtova, Martina, Královec, Karel, Habartova, Klara, Cahlikova, Lucie, Rezacova, Martina |
| بيانات النشر: | 2018-02-27T03:39:10Z 2018-02-27T03:39:10Z 2017 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | This study focuses on the comparative in vitro cytotoxicity of chelidonine and homochelidonine on human cancer and non-cancer cells. Both alkaloids produced a decrease in cellular growth in a dose-dependent manner exhibiting greater potency in cancer cells. The growth inhibitory effect was evidenced in both ovarian carcinoma A2780 and lung fibroblast MRC-5 cells by inducing G2 and mitotic phase cell cycle arrest. Results indicated that the extent of apoptosis induced by chelidonine and homochelidonine was correlated to sensitivity to the antiproliferative activity of the evaluated compounds. Western blotting suggested that the cellular toxicological mechanism of chelidonine is related to the differential upregulation of phospho-Chk2, p21(Cip1/Waf1), phospho-ERK1/2 and phospho-p38 in various cell types, leading to alternations in the suppression of proliferation and either induction or prevention of apoptosis. Chelidonine showed the more potent effects and also affected the cell cycle checkpoints and MAPK signaling pathways within cells. Tato práce je zaměřena na srovnávací cytotoxicitu chelidoninu a homochelidoninu na lidských nádorových a nenádorových buňkách. |
| مصطلحات الفهرس: | Chelidonine, Homochelidonine, In vitro, Antiproliferative activity, Mitogen-activated protein kinases, Chelidonin, Homochelidonin, Antiproliferační aktivita, Mitogenem aktivovaná proteinkináza, article |
| URL: | Natural Product Communications, volume 12, issue: 9 |
| الإتاحة: | Open access content. Open access content Práce není přístupná |
| ملاحظة: | p. 1419-1430 application/pdf English |
| أرقام أخرى: | CZPAR oai:dk.upce.cz:10195/70273 1934-578X 000412968400010 2-s2.0-85030688926 39879162 1100076031 |
| المصدر المساهم: | UNIV LIBR OF THE UNIV OF PARDUBICE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1100076031 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |