مورد إلكتروني
Serum fetuin-A levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients
| العنوان: | Serum fetuin-A levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients |
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| المؤلفون: | UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de radiologie, Marechal, Cécine, Schlieper, Georg, Nguyen, Pauline, Krüger, Thilo, Coche, Emmanuel, Robert, Annie, Floege, Jorgen, Goffin, Eric, Jadoul, Michel, Devuyst, Olivier |
| المصدر: | Clinical Journal of the American Society of Nephrology, Vol. 6, no. 5, p. 974-985 (2011) |
| بيانات النشر: | American Society of Nephrology 2011 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND AND OBJECTIVES: Vascular calcifications predict cardiovascular disease, the major cause of death in renal transplant recipients (RTRs). We studied the determinants of fetuin-A, a potent circulating calcification inhibitor encoded by the AHSG gene, and tested its association with vascular calcifications and long-term survival and cardiovascular events (CVEs) in RTRs. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Two hundred seventy-seven prevalent RTRs from a single center were included. CVEs and deaths were prospectively recorded during a 5-year follow-up. RESULTS: Independent determinants of lower serum fetuin-A levels were lower plasma cholesterol, the AHSG rs4918 G allele, and history of smoking. Low serum fetuin-A level was a determinant of aortic calcifications (assessed using spiral CT). Low fetuin-A levels (≤0.47 g/L, first quintile) were independently associated with CVEs and deaths (hazard ratio=1.83; 95% confidence interval, 1.07 to 3.04). The association was confirmed for all-cause mortality, and the major adverse cardiovascular endpoints were analyzed separately. Patients with low fetuin-A and high high-sensitivity C-reactive protein (>4.36 mg/L, fourth quintile) levels had a 3.5-fold increased risk of all-cause mortality and CVEs. In the presence of inflammation, CVE-free survival was influenced by common variants in the AHSG gene. CONCLUSIONS: These data show that low fetuin-A levels are independently associated with aortic calcifications and a higher risk of CVEs and mortality. They support fetuin-A as a circulating biomarker able to identify RTRs at risk for vascular calcifications and CVEs. |
| مصطلحات الفهرس: | Adult, Aortic Diseases - blood, genetics, mortality, Kaplan-Meier Estimate, Kidney Transplantation - mortality, Linkage Disequilibrium, Male, Middle Aged, Predictive Value of Tests, Prevalence, Prospective Studies, Risk Factors, alpha-2-HS-Glycoprotein, Biological Markers - blood, Blood Proteins - genetics, metabolism, Calcinosis - blood, genetics, mortality, Cholesterol - blood, Cohort Studies, Female, Genetic Predisposition to Disease - epidemiology, Humans, info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| أرقام أخرى: | UCDLC oai:dial.uclouvain.be:boreal:113241 boreal:113241 info:doi/10.2215/CJN.06150710 info:pmid/21527649 urn:ISSN:1555-9041 urn:EISSN:1555-905X 1130512353 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1130512353 |
| قاعدة البيانات: | OAIster |
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