مورد إلكتروني
Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
| العنوان: | Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses |
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| المؤلفون: | Samardžija, Marko, Lojkić, Martina, Maćešić, Nino, Valpotić, Hrvoje, Butković, Ivan, Šavorić, Juraj, Žura Žaja, Ivona, Leiner, Denis, Đuričić, Dražen, Marković, Franjo, Kočila, Predrag, Vidas, Željko, Gerenčer, Marijan, Kaštelan, Andrija, Milovanović, Aleksandar, Lazarević, Miodrag, Rukavina, Daniel, Valpotić, Ivica |
| المصدر: | Veterinary Quarterly |
| بيانات النشر: | Taylor & Francis 2020 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals. |
| مصطلحات الفهرس: | allogeneic gamete, CD45, immunotrophism, Reproductive immunology, semiallogeneic foetus, transplantation immunology, viviparous mammals, article |
| URL: | |
| الإتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by-nc/4.0 BY-NC openAccess |
| ملاحظة: | Veterinary Quarterly |
| أرقام أخرى: | RSPST oai:vet-erinar.vet.bg.ac.rs:123456789/1967 0165-2176 https://vet-erinar.vet.bg.ac.rs/handle/123456789/1967 000596859900001 10.1080/01652176.2020.1852336 2-s2.0-85097384464 https://vet-erinar.vet.bg.ac.rs/bitstream/id/5246/Reproductive_immunology_in_pub_2020.pdf 1232150383 |
| المصدر المساهم: | UIVERSITY OF BELGRADE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1232150383 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |