مورد إلكتروني
The role of Six1 in muscle progenitor cells and the establishment of fast-twitch muscle fibres
| العنوان: | The role of Six1 in muscle progenitor cells and the establishment of fast-twitch muscle fibres |
|---|---|
| المؤلفون: | Nord, Hanna |
| بيانات النشر: | Umeå universitet, Umeå centrum för molekylär medicin (UCMM) Umeå : Umeå Universitet 2014 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Myogenesis is the process of skeletal muscle tissue formation where committed muscle progenitor cells differentiate into skeletal muscle fibres. Depending on the instructive cues the muscle progenitor cells receive they will differentiate into specific fibre types with different properties. The skeletal muscle fibres can be broadly classified as fast-twitch fibres or slow-twitch fibres, based on their contractile speed. However, subgroups of fast- and slow-twitch fibres with different metabolic properties, endurance and different isoforms of sarcomeric components have also been identified, adding complexity to the process of muscle tissue patterning. The skeletal muscle tissue has the capacity to regenerate throughout life. Upon muscle tissue damage muscle satellite cells are recruited to the area of injury where they proliferate and either form new fibres similar to those damaged, or fuse with existing fibres. This thesis aims to investigate the process of muscle progenitor cell proliferation and differentiation, as well as the fast-twitch fibre formation and muscle tissue patterning in the zebrafish embryo. I present results identifying the previously uncharacterised gene myl1, encoding an alkali-like myosin light chain, which is specifically expressed in fast-twitch muscle progenitors before fibre formation. Furthermore, I introduce data showing that the transcription factor six1 is expressed in Pax7+ muscle progenitor cells, which has been reported to contribute to part of the fast-twitch muscle tissue as well as to a pool of quiescent muscle satellite cells. With support from the presented data, I hypothesise that six1 keeps the Pax7+ muscle progenitor cells in a proliferative state and consequently prevents them from differentiating into muscle fibres. In addition, I demonstrate that the zebrafish fast-twitch muscle fibres can be divided into different subgroups that express unique forms of fast myosin heavy chain genes along the anterior-posterior (head-tail) |
| مصطلحات الفهرس: | Myogenesis, zebrafish, muscle fibre, patterning, fmyhc, myl1, Six1, Pax7, Basic Medicine, Medicinska och farmaceutiska grundvetenskaper, Doctoral thesis, comprehensive summary, info:eu-repo/semantics/doctoralThesis, text |
| URL: | Umeå University medical dissertations, 0346-6612 ; 1684 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UPE oai:DiVA.org:umu-95849 urn:isbn:978-91-7601-161-4 1234372931 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1234372931 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |