مورد إلكتروني

Latent tuberculosis infection screening in persons newly-diagnosed with HIV infection in Italy: A multicentre study promoted by the Italian Society of Infectious and Tropical Diseases

التفاصيل البيبلوغرافية
العنوان: Latent tuberculosis infection screening in persons newly-diagnosed with HIV infection in Italy: A multicentre study promoted by the Italian Society of Infectious and Tropical Diseases
المؤلفون: Goletti, D, Navarra, A, Petruccioli, E, Cimaglia, C, Compagno, M, Cuzzi, G, De Carli, G, Fondaco, L, Franzetti, F, Giannetti, A, Gori, A, Lapadula, G, Lichtner, M, Mastroianni, C, Mazzotta, V, Orchi, N, Pavone, P, Piacentini, D, Pirriatore, V, Pontali, E, Sarmati, L, Spolti, A, Tacconelli, E, Galli, M, Antinori, A, Calcagno, A, Girardi, E, Goletti D., Navarra A., Petruccioli E., Cimaglia C., Compagno M., Cuzzi G., De Carli G., Fondaco L., Franzetti F., Giannetti A., Gori A., Lapadula G., Lichtner M., Mastroianni C. M., Mazzotta V., Orchi N., Pavone P., Piacentini D., Pirriatore V., Pontali E., Sarmati L., Spolti A., Tacconelli E., Galli M., Antinori A., Calcagno A., Girardi E.
بيانات النشر: Elsevier B.V. 2020
نوع الوثيقة: Electronic Resource
مستخلص: Background: The Italian Society of Infectious and Tropical Diseases performed a survey on the application of guidelines for the management of persons living with HIV (PLWH), to evaluate current practice and the yield of screening for latent tuberculosis infection (LTBI) in newly-diagnosed PLWH; in addition, the offer of preventive therapy to LTBI individuals and the completion rate were analysed. Materials and methods: Newly-diagnosed PLWH in nine centres were evaluated retrospectively (2016/2017) using binary and multinomial logistic regression to identify factors associated with LTBI diagnostic screening and QuantiFERON (QFT) results. Results: Of 801 patients evaluated, 774 were studied after excluding active TB. LTBI tests were performed in 65.5%. Prescription of an LTBI test was associated with being foreign-born (odds ratio (OR) 3.19, p < 0.001), older (for 10-year increments, OR 1.22, p = 0.034), and having a CD4 count <100 cells/mm3 vs ≥500 cells/mm3 (OR 2.30, p = 0.044). LTBI was diagnosed in 6.5% of 495 patients evaluated by QFT. Positive results were associated with being foreign-born (relative risk ratio (RRR) 30.82, p < 0.001), older (for 10-year increments, RRR 1.78, p = 0.003), and having a high CD4 count (for 100 cells/mm3 increments, RRR 1.26, p < 0.003). Sixteen LTBI individuals started TB preventive therapy and eight completed it. Conclusions: LTBI screening is inconsistently performed in newly-diagnosed PLWH. Furthermore, TB preventive therapy is not offered to all LTBI individuals and compliance is poor.
مصطلحات الفهرس: Active TB, CD4 T-cell, HIV, IGRA, Latency, LTBI, Quantiferon, Tuberculosi, Adult, CD4 Lymphocyte Count, Female, HIV Infection, Human, Italy, Latent Tuberculosi, Male, Mass Screening, Middle Aged, Retrospective Studie, Sexual and Gender Minoritie, Tuberculin Test, info:eu-repo/semantics/article
URL: http://hdl.handle.net/10281/326198
info:eu-repo/semantics/altIdentifier/pmid/31887456
info:eu-repo/semantics/altIdentifier/wos/WOS:000519191900011
volume:92
firstpage:62
lastpage:68
numberofpages:7
journal:INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
الإتاحة: Open access content. Open access content
ملاحظة: English
أرقام أخرى: ITBAO oai:boa.unimib.it:10281/326198
10.1016/j.ijid.2019.12.031
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078679730
1308940673
المصدر المساهم: BICOCCA OPEN ARCH
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رقم الأكسشن: edsoai.on1308940673
قاعدة البيانات: OAIster