مورد إلكتروني
The interrelationship of smoking, CD4(+) cell count, viral load and cancer in persons living with HIV
| العنوان: | The interrelationship of smoking, CD4(+) cell count, viral load and cancer in persons living with HIV |
|---|---|
| المؤلفون: | Mocroft, A., Wit, F., Vehreschild, J. J., Guaraldi, G., Miro, J. M., Greenberg, L., Oellinger, A., Egle, A., Guenthard, H. F., Bucher, H. C., De Wit, S., Necsoi, C., Castagna, A., Spagnuolo, V, Monforte, A. D'Arminio, Reiss, P., Chkhartishvili, N., Bolokadze, N., Hoy, J., Sonnenborg, A., Svedhem, V, Bower, M., Volny-Anne, A., Garges, H., Rogatto, F., Neesgaard, B., Peters, L., Lundgren, J. D., Ryom, L. |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: It is unknown if the carcinogenic effect of smoking is influenced by CD4(+) cell count and viral load in persons living with HIV. Material and methods: RESPOND participants with known smoking status were included. Poisson regression adjusting for baseline confounders investigated the interaction between current CD4(+)/viral load strata [good (CD4(+) cell count >= 500 cells/mu l and viral load <200 copies/ml], poor [CD4(+) cell count <= 350 cells/mu l and viral load >200 copies/ml] and intermediate [all other combinations]), smoking status and all cancers, non-AIDS defining cancers (NADCs), smoking-related cancers (SRCs) and infection-related cancers (IRCs). Results: Out of 19 602 persons, 41.3% were never smokers, 44.4% current and 14.4% previous smokers at baseline. CD4(+)/viral load strata were poor in 3.4%, intermediate in 44.8% and good in 51.8%. There were 513 incident cancers; incidence rate 6.9/1000 person-years of follow-up (PYFU) [95% confidence interval (95% CI) 6.3-7.5]. Current smokers had higher incidence of all cancer (adjusted incidence rate ratio 1.45; 1.17-1.79), NADC (1.65; 1.31-2.09), SRC (2.21; 1.53-3.20) and IRC (1.38; 0.97-1.96) vs. never smokers. Those with poor CD4(+)/viral load had increased incidence of all cancer (5.36; 95% CI 3.71-7.75), NADC (3.14; 1.92-5.14), SRC (1.82; 0.76-4.41) and IRC (10.21; 6.06-17.20) vs. those with good CD4(+)/viral load. There was no evidence that the association between smoking and cancer subtypes differed depending on the CD4(+)/viral load strata (P > 0.1, test for interaction). Conclusion: In the large RESPOND consortium, the impact of smoking on cancer was clear and reducing smoking rates should remain a priority. The association between current immune deficiency, virological control and cancer was similar for never smokers, current smokers and previous smokers suggesting similar carcinogenic effects of smoking regardless of CD4(+) cell count and viral load. |
| مصطلحات الفهرس: | ddc:no, doc-type:article, publishedVersion |
| URL: | 10.1097/QAD.0000000000002791 |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | K7U oai:USBKOELN.ub.uni-koeln.de:60614 Mocroft, A., Wit, F., Vehreschild, J. J., Guaraldi, G., Miro, J. M., Greenberg, L., Oellinger, A., Egle, A., Guenthard, H. F., Bucher, H. C., De Wit, S., Necsoi, C., Castagna, A., Spagnuolo, V, Monforte, A. D'Arminio, Reiss, P., Chkhartishvili, N., Bolokadze, N., Hoy, J., Sonnenborg, A., Svedhem, V, Bower, M., Volny-Anne, A., Garges, H., Rogatto, F., Neesgaard, B., Peters, L., Lundgren, J. D. and Ryom, L. (2021). The interrelationship of smoking, CD4(+) cell count, viral load and cancer in persons living with HIV. Aids, 35 (5). S. 747 - 758. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571 1312208146 |
| المصدر المساهم: | UNIVERSITATS- UND STADTBIBLIOTHEK KOLN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1312208146 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |