مورد إلكتروني
Honey Bee Products : Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties
| العنوان: | Honey Bee Products : Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties |
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| المؤلفون: | El-Seedi, Hesham, Eid, Nehal, Abd El-Wahed, Aida A., Rateb, Mostafa E., Afifi, Hanan S., Algethami, Ahmed F., Zhao, Chao, Al Naggar, Yahya, Alsharif, Sultan M., Tahir, Haroon Elrasheid, Xu, Baojun, Wang, Kai, Khalifa, Shaden A. M. |
| بيانات النشر: | Uppsala universitet, Institutionen för farmaceutisk biovetenskap Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Peoples R China.;Jiangsu Univ, Int Joint Res Lab Intelligent Agr & Agri Prod Pro, Jiangsu Educ Dept, Zhenjiang, Peoples R China.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt. Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt. Plant Protect Res Inst, Agr Res Ctr, Dept Bee Res, Giza, Egypt. Univ West Scotland, Sch Comp Engn & Phys Sci, Paisley, Renfrew, Scotland. Abu Dhabi Agr & Food Safety Author ADAFSA, R&D Div, Food Res Sect, Abu Dhabi, U Arab Emirates. Alnahalaljwal Fdn Saudi Arabia, Mecca, Saudi Arabia. Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou, Peoples R China. Martin Luther Univ Halle Wittenberg, Inst Biol, Gen Zool Grp, Halle, Germany.;Tanta Univ, Fac Sci, Zool Dept, Tanta, Egypt. Taibah Univ, Fac Sci, Biol Dept, Medina, Saudi Arabia. Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China. BNU HKBU United Int Coll, Programme Food Sci & Technol, Zhuhai, Peoples R China. Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China. Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden. FRONTIERS MEDIA SA 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Inflammation is a defense process triggered when the body faces assaults from pathogens, toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory disorders are common pathogenic pathways that lead to the progress of various chronic diseases, such as cancer and diabetes. The overproduction of cytokines, such as interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha, is an essential parameter in the clinical diagnosis of auto-inflammatory diseases. In this review, the effects of bee products have on inflammatory and autoimmune diseases are discussed with respect to the current literature. The databases of Google Scholar, PubMed, Science Direct, Sci-Finder and clinical trials were screened using different combinations of the following terms: "immunomodulatory", "anti-inflammatory", "bee products", "honey", "propolis", "royal jelly", "bee venom", "bee pollen", "bee bread", "preclinical trials", "clinical trials", and "safety". Honey bee products, including propolis, royal jelly, honey, bee venom, and bee pollen, or their bioactive chemical constituents like polyphenols, demonstrate interesting therapeutic potential in the regulation of inflammatory mediator production as per the increase of TNF-alpha, IL-1 beta, IL-6, Il-2, and Il-7, and the decrease of reactive oxygen species (ROS) production. Additionally, improvement in the immune response via activation of B and T lymphocyte cells, both in in vitro, in vivo and in clinical studies was reported. Thus, the biological properties of bee products as anti-inflammatory, immune protective, antioxidant, anti-apoptotic, and antimicrobial agents have prompted further clinical investigation. |
| مصطلحات الفهرس: | bee products, inflammation, diabetes, hypertension, cancer, preclinical and clinical studies, safety, Rheumatology and Autoimmunity, Reumatologi och inflammation, Article, review/survey, info:eu-repo/semantics/article, text |
| DOI: | 10.3389.fnut.2021.761267 |
| URL: | Frontiers in Nutrition, 2022, 8 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-467138 0000-0002-2519-6690 doi:10.3389/fnut.2021.761267 PMID 35047540 ISI:000745695500001 1312845185 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1312845185 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.3389.fnut.2021.761267 |
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