مورد إلكتروني
Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis
| العنوان: | Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis |
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| المؤلفون: | Kowalski, GM, Hamley, S, Selathurai, A, Kloehn, J, De Souza, DP, O'Callaghan, S, Nijagal, B, Tull, DL, McConville, MJ, Bruce, CR |
| بيانات النشر: | NATURE PUBLISHING GROUP 2016-06-07 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Using a combination of stable isotope, and targeted metabolomic approaches we investigated the acute (7-9 days) hepatic effects of switching high-fat high-sucrose diet (HFD) fed obese mice back to a chow diet. Upon the switch, energy intake was reduced, resulting in reductions of fat mass and hepatic triacyl- and diacylglycerol. However, these parameters were still elevated compared to chow fed mice, thus representing an intermediate phenotype. Nonetheless, glucose intolerance and hyperinsulinemia were completely normalized. The diet reversal resulted in marked reductions in hepatic de novo lipogenesis when compared to the chow and HFD groups. Compared with HFD, glycerolipid synthesis was reduced in the reversal animals, however it remained elevated above that of chow controls, indicating that despite experiencing a net loss in lipid stores, the liver was still actively esterifying available fatty acids at rates higher than that in chow control mice. This effect likely promotes the re-esterification of excess free fatty acids released from the breakdown of adipose depots during the weight loss period. |
| مصطلحات الفهرس: | Journal Article |
| URL: | NHMRC/1059530 |
| الإتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/259325 Kowalski, G. M., Hamley, S., Selathurai, A., Kloehn, J., De Souza, D. P., O'Callaghan, S., Nijagal, B., Tull, D. L., McConville, M. J. & Bruce, C. R. (2016). Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep27541. 10.1038/srep27541 2045-2322 2045-2322 1315673472 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315673472 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |