مورد إلكتروني
Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy
| العنوان: | Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy |
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| المؤلفون: | Chong, WC, Jayasekara, WSN, Vaghjiani, VG, Parackal, S, Sun, C, Popovski, D, Algar, EM, Firestein, R, Wood, PJ, Khan, S, Huang, A, Ashley, DM, Downie, P, Cain, JE |
| بيانات النشر: | MDPI 2021-10-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Atypical teratoid rhabdoid tumour (ATRT) is a rare but highly aggressive undifferentiated solid tumour arising in the central nervous system and predominantly affecting infants and young children. ATRT is exclusively characterized by the inactivation of SMARCB1, a member of the SWI/SNF chromatin remodelling complex that is essential for the regulation of large sets of genes required for normal development and differentiation. Histone deacetylase inhibitors (HDACi) are a promising anticancer therapy and are able to mimic the normal acetylation functions of SMARCB1 in SMARCB1-deficient cells and drive multilineage differentiation in extracranial rhabdoid tumours. However, the potential efficacy of HDACi in ATRT is unknown. Here, we show that human ATRT cells are highly responsive to the HDACi panobinostat and that sustained treatment leads to growth arrest, increased cell senescence, decreased clonogenicity and induction of a neurogenesis gene-expression profile. Furthermore, in an orthotopic ATRT xenograft model, continuous panobinostat treatment inhibits tumour growth, increases survival and drives neuronal differentiation as shown by the expression of the neuronal marker, TUJ1. Collectively, this preclinical study supports the therapeutic potential of panobinostat-mediated differentiation therapy for ATRT. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/301894 Chong, W. C., Jayasekara, W. S. N., Vaghjiani, V. G., Parackal, S., Sun, C., Popovski, D., Algar, E. M., Firestein, R., Wood, P. J., Khan, S., Huang, A., Ashley, D. M., Downie, P. & Cain, J. E. (2021). Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy. CANCERS, 13 (20), https://doi.org/10.3390/cancers13205145. 10.3390/cancers13205145 2072-6694 2072-6694 1315675851 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1315675851 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |