مورد إلكتروني
Fluorescent light energy modulates healing in skin grafted mouse model
| العنوان: | Fluorescent light energy modulates healing in skin grafted mouse model |
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| المصدر: | Ding , J , Mellergaard , M , Zhu , Z , Kwan , P , Edge , D , Ma , Z , Hebert , L , Alrobaiea , S , Iwasaki , T , Nielsen , M C E & Tredget , E E 2021 , ' Fluorescent light energy modulates healing in skin grafted mouse model ' , Open Medicine , vol. 16 , no. 1 , pp. 1240-1255 . |
| بيانات النشر: | 2021 |
| تفاصيل مُضافة: | Ding, Jie Mellergaard, Maiken Zhu, Zhensen Kwan, Peter Edge, Deirdre Ma, Zengshuan Hebert, Lise Alrobaiea, Saad Iwasaki, Takashi Nielsen, Michael Canova Engelbrecht Tredget, Edward E. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-Thickness human skin grafts were transplanted onto full-Thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring. |
| مصطلحات الفهرس: | dermal fibrotic mouse model, fluorescent light energy, photobiomodulation, skin grafting, wound healing, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | DAV oai:pure.atira.dk:publications/ef0f4476-5262-43cd-8d48-a2d0c3b02d4d 1322765998 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1322765998 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |