مورد إلكتروني
Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis
| العنوان: | Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis |
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| المؤلفون: | Giani, M, Rezoagli, E, Guervilly, C, Rilinger, J, Duburcq, T, Petit, M, Textoris, L, Garcia, B, Wengenmayer, T, Grasselli, G, Pesenti, A, Combes, A, Foti, G, Schmidt, M, Bellani, G, Martucci, G, Arcadipane, A, Lucchini, A, Garofalo, E, Belliato, M, Fanelli, V, Papazian, L, Forel, J, Hraiech, S, Roch, A, Prud'Homme, E, Luyt, C, Hekimian, G, Chommeloux, J, Pineton de Chambrun, M, Brechot, N, Staudacher, D, Supady, A, Biever, P, Zotzmann, V, Bemtgen, X, Sekandarzad, A, Kruger, K, Flugler, A, Parmentier-Decrucq, E, Poissy, J, Gaudet, A, Moussa, M, Vincentelli, A, Giani M., Rezoagli E., Guervilly C., Rilinger J., Duburcq T., Petit M., Textoris L., Garcia B., Wengenmayer T., Grasselli G., Pesenti A., Combes A., Foti G., Schmidt M., Bellani G., Martucci G., Arcadipane A., Lucchini A., Garofalo E., Belliato M., Fanelli V., Papazian L., Forel J. -M., Hraiech S., Roch A., Prud'homme E., Luyt C. E., Hekimian G., Chommeloux J., Pineton de Chambrun M., Brechot N., Staudacher D. L., Supady A., Biever P., Zotzmann V., Bemtgen X., Sekandarzad A., Kruger K., Flugler A., Parmentier-Decrucq E., Poissy J., Gaudet A., Moussa M. D., Vincentelli A. |
| بيانات النشر: | BioMed Central Ltd country:US 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit of prone positioning maneuvers during venovenous extracorporeal membrane oxygenation (ECMO) is unknown. The aim of this study was to evaluate the association between the use of prone positioning during extracorporeal support and ICU mortality in a pooled population of patients from previous European cohort studies. Methods: We performed a pooled individual patient data analysis of European cohort studies which compared patients treated with prone positioning during ECMO (Prone group) to “conventional” ECMO management (Supine group) in patients with severe ARDS. Results: 889 patients from five studies were included. Unadjusted ICU mortality was 52.8% in the Supine Group and 40.8% in the Prone group. At a Cox multiple regression analysis PP during ECMO was not significantly associated with a reduction of ICU mortality (HR 0.67 95% CI: 0.42–1.06). Propensity score matching identified 227 patients in each group. ICU mortality of the matched samples was 48.0% and 39.6% for patients in the Supine and Prone group, respectively (p = 0.072). Conclusions: In a large population of ARDS patients receiving venovenous extracorporeal support, the use of prone positioning during ECMO was not significantly associated with reduced ICU mortality. The impact of this procedure will have to be definitively assessed by prospective randomized controlled trials. |
| مصطلحات الفهرس: | Acute respiratory distress syndrome, Extracorporeal membrane oxygenation, Mortality, Pooled data analysi, Prone positioning, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/34986895 info:eu-repo/semantics/altIdentifier/wos/WOS:000739404300001 volume:26 issue:1 (December 2022) journal:CRITICAL CARE |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | STAMPA English |
| أرقام أخرى: | ITBAO oai:boa.unimib.it:10281/394153 10.1186/s13054-021-03879-w info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85122469893 1350080482 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1350080482 |
| قاعدة البيانات: | OAIster |
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