مورد إلكتروني
Standard ECG for differential diagnosis between Anderson-Fabry disease and hypertrophic cardiomyopathy
| العنوان: | Standard ECG for differential diagnosis between Anderson-Fabry disease and hypertrophic cardiomyopathy |
|---|---|
| المؤلفون: | Vitale, Giovanni, Ditaranto, Raffaello, Graziani, Francesca, Tanini, Ilaria, Camporeale, Antonia, Lillo, Rosa, Rubino, Marta, Panaioli, Elena, Di Nicola, Federico, Ferrara, Valentina, Zanoni, Rossana, Caponetti, Angelo Giuseppe, Pasquale, Ferdinando, Graziosi, Maddalena, Berardini, Alessandra, Ziacchi, Matteo, Biffi, Mauro, Santostefano, Marisa, Liguori, Rocco, Taglieri, Nevio, Nardi, Elena, Linhart, Ale, Olivotto, Iacopo, Rapezzi, Claudio, Biagini, Elena, Graziani, Francesca (ORCID:0000-0002-4520-5689) |
| بيانات النشر: | BMJ PUBLISHING GROUP 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objectives To evaluate the role of the ECG in the differential diagnosis between Anderson-Fabry disease (AFD) and hypertrophic cardiomyopathy (HCM). Methods In this multicentre retrospective study, 111 AFD patients with left ventricular hypertrophy were compared with 111 patients with HCM, matched for sex, age and maximal wall thickness by propensity score. Independent ECG predictors of AFD were identified by multivariate analysis, and a multiparametric ECG score-based algorithm for differential diagnosis was developed. Results Short PR interval, prolonged QRS duration, right bundle branch block (RBBB), R in augmented vector left (aVL) >= 1.1 mV and inferior ST depression independently predicted AFD diagnosis. A point-by-point ECG score was then derived with the following diagnostic performances: c-statistic 0.80 (95% CI 0.74 to 0.86) for discrimination, the Hosmel-Lemeshow chi(2) 6.14 (p=0.189) for calibration, sensitivity 69%, specificity 84%, positive predictive value 82% and negative predictive value 72%. After bootstrap resampling, the mean optimism was 0.025, and the internal validated c-statistic for the score was 0.78. Conclusions Standard ECG can help to differentiate AFD from HCM while investigating unexplained left ventricular hypertrophy. Short PR interval, prolonged QRS duration, RBBB, R in aVL >= 1.1 mV and inferior ST depression independently predicted AFD. Their systematic evaluation and the integration in a multiparametric ECG score can support AFD diagnosis. |
| مصطلحات الفهرس: | cardiomyopathy, electrocardiography, genetic diseases, hypertrophic, inborn, metabolic diseases, Bundle-Branch Block, Diagnosis, Differential, Electrocardiography, Humans, Hypertrophy, Left Ventricular, Retrospective Studies, Cardiomyopathy, Hypertrophic, Fabry Disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/33563631 info:eu-repo/semantics/altIdentifier/wos/WOS:000727454800001 volume:108 issue:1 firstpage:54 lastpage:60 numberofpages:7 issueyear:2022 journal:HEART |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | SYC oai:publicatt.unicatt.it:10807/214624 10.1136/heartjnl-2020-318271 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100712917 1355229382 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1355229382 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |