مورد إلكتروني
The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications
| العنوان: | The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications |
|---|---|
| المؤلفون: | van der Veen, A., Schiffmann, L. M., de Groot, E. M., Bartella, I, de Jong, P. A., Borggreve, A. S., Brosens, L. A. A., Dos Santos, D. Pinto, Fuchs, H., Ruurda, J. P., Bruns, C. J., van Hillegersberg, R., Schroeder, W. |
| بيانات النشر: | BMC 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Anastomotic leakage is the most important surgical complication following esophagectomy. A major cause of leakage is ischemia of the gastric tube that is used for reconstruction of the gastrointestinal tract. Generalized cardiovascular disease, expressed by calcifications of the aorta and celiac axis stenosis on a pre-operative CT scan, is associated with an increased risk of anastomotic leakage. Laparoscopic ischemic conditioning (ISCON) aims to redistribute blood flow and increase perfusion at the anastomotic site by occluding the left gastric, left gastroepiploic and short gastric arteries prior to esophagectomy. This study aims to assess the safety and feasibility of laparoscopic ISCON in selected patients with esophageal cancer and concomitant arterial calcifications. Methods: In this prospective single-arm safety and feasibility trial based upon the IDEAL recommendations for surgical innovation, a total of 20 patients will be included recruited in 2 European high-volume centers for esophageal cancer surgery. Patients with resectable esophageal carcinoma (cT1-4a, N0-3, M0) with major calcifications of the thoracic aorta accordingly to the Uniform Calcification Score (UCS) or a stenosis of the celiac axis accordingly to the modified North American Symptomatic Carotid Endarterectomy Trial (NASCET) score on preoperative CT scan, who are planned to undergo esophagectomy are eligible for inclusion. The primary outcome variables are complications grade 2 and higher (Clavien-Dindo classification) occurring during or after laparoscopic ISCON and before esophagectomy. Secondary outcomes include intra- and postoperative complications of esophagectomy and the induction of angiogenesis by biomarkers of microcirculation and redistribution of blood flow by measurement of indocyanine green (ICG) fluorescence angiography. Discussion: We hypothesize that in selected patients with impaired vascularization of the gastric tube, laparoscopic ISCON is feasible and can be |
| مصطلحات الفهرس: | ddc:no, doc-type:article, publishedVersion |
| URL: | 10.1186/s12885-022-09231-x |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | K7U oai:USBKOELN.ub.uni-koeln.de:67609 van der Veen, A., Schiffmann, L. M., de Groot, E. M., Bartella, I, de Jong, P. A., Borggreve, A. S., Brosens, L. A. A., Dos Santos, D. Pinto, Fuchs, H., Ruurda, J. P., Bruns, C. J., van Hillegersberg, R. and Schroeder, W. (2022). The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications. BMC Cancer, 22 (1). LONDON: BMC. ISSN 1471-2407 1383743331 |
| المصدر المساهم: | UNIVERSITATS- UND STADTBIBLIOTHEK KOLN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1383743331 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |