مورد إلكتروني
The Gut-Vascular Barrier as a New Protagonist in Intestinal and Extraintestinal Diseases
| العنوان: | The Gut-Vascular Barrier as a New Protagonist in Intestinal and Extraintestinal Diseases |
|---|---|
| بيانات النشر: | MDPI 2023 |
| تفاصيل مُضافة: | Di Tommaso, Natalia Santopaolo, Francesco Gasbarrini, Antonio Ponziani, Francesca Romana Di Tommaso, Natalia Santopaolo, Francesco Gasbarrini, Antonio (ORCID:0000-0002-7278-4823) Ponziani, Francesca Romana (ORCID:0000-0002-5924-6238) |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The intestinal barrier, with its multiple layers, is the first line of defense between the outside world and the intestine. Its disruption, resulting in increased intestinal permeability, is a recognized pathogenic factor of intestinal and extra-intestinal diseases. The identification of a gut-vascular barrier (GVB), consisting of a structured endothelium below the epithelial layer, has led to new evidence on the etiology and management of diseases of the gut-liver axis and the gut-brain axis, with recent implications in oncology as well. The gut-brain axis is involved in several neuroinflammatory processes. In particular, the recent description of a choroid plexus vascular barrier regulating brain permeability under conditions of gut inflammation identifies the endothelium as a key regulator in maintaining tissue homeostasis and health. |
| مصطلحات الفهرس: | GVB: gut–vascular barrier, PV-1: plasmalemma vesicle-associated protein-1, PVB: choroid plexus vascular barrier, endothelium, neuroinflammation, Settore MED/12 - GASTROENTEROLOGIA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/36674986 info:eu-repo/semantics/altIdentifier/wos/WOS:000915125000001 volume:24 issue:2 firstpage:1470 lastpage:N/A issueyear:N/A journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | SYC oai:publicatt.unicatt.it:10807/241359 10.3390/ijms24021470 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85146515047 1397545444 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1397545444 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |