دورية أكاديمية
Hepatitis B virus and hepatitis C virus infection in Belgium: similarities and differences in epidemic and initial management
| العنوان: | Hepatitis B virus and hepatitis C virus infection in Belgium: similarities and differences in epidemic and initial management |
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| المؤلفون: | De Vroey, B, Moreno, C, Laleman, W, Van Gossum, M, Colle, I, de Galocsy, C, Langlet, P, Robaeys, G, Orlent, H, Michielsen, P, DELWAIDE, Jean, Reynaert, H, D'Heygere, F, Sprengers, D, Bourgeois, S, Assene, C, Vos, B, Brenard, R, Adler, M, Henrion, J, Deltenre, P |
| المصدر: | European Journal of Gastroenterology and Hepatology, 25 (5), 613-619 (2013-05) |
| بيانات النشر: | Lippincott Williams & Wilkins, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | epidemiology, liver biopsy, management, screening, viral hepatitis, Human health sciences, Gastroenterology & hepatology, Sciences de la santé humaine, Gastroentérologie & hépatologie |
| الوصف: | Introduction Nationwide studies comparing patients withhepatitis B and C virus (HBV and HCV) infections aremandatory for assessing changes in epidemiology.Aim The aim of this study was to compare epidemiologicaldata and initial management of newly diagnosed patientswith persistent HBV (HBsAg positive) or HCV (detectableHCV RNA) infection in Belgium.Patients and methods Data were extracted from twoBelgian observational databases.Results A total of 655 patients (387 HBV and 268 HCV)were included. Compared with HCV patients, HBV patientswere younger, more frequently men, more often of Asian orAfrican origin (43 vs. 10%, P < 0.0001), and less frequentlycontaminated by transfusion or intravenous drug use(9 and 6% vs. 34 and 44%, P< 0.0001). Viral replication wasassessed in 89% of HBV patients. Compared with HCVpatients, HBV patients more frequently had normal alanineaminotransferase (ALT) levels (65 vs. 29%, P < 0.0001), lessfrequently underwent liver biopsy (29 vs. 67%, P < 0.0001),and were less often considered for antiviral therapy(25 vs. 54%, P < 0.0001). When taking only HBV patientswith detectable viral replication into consideration, resultsremained unchanged. During the multivariate analysis,ALT was a major factor for performing liver biopsy orconsidering antiviral therapy in both groups.Conclusion HBV and HCV screening policies should betargeted toward immigrants and intravenous drug users,respectively. Guidelines recommending systematic searchfor viral replication should be reinforced in HBV patients.HBV patients less frequently underwent liver biopsy andwere less often considered for antiviral therapy comparedwith HCV patients. Despite the lack of sensitivity andspecificity, ALT remains a pivotal decision-making tool forliver biopsy and antiviral therapy in both infections. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | urn:issn:0954-691X; urn:issn:1473-5687 |
| DOI: | 10.1097/MEG.0b013e32835d83a2 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/153653 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.153653 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1097/MEG.0b013e32835d83a2 |
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