دورية أكاديمية
Super-high-risk germ-cell tumors: a clinical entity. Report of eleven cases.
| العنوان: | Super-high-risk germ-cell tumors: a clinical entity. Report of eleven cases. |
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| المؤلفون: | Moran-Ribon, A, Droz, J P, Kattan, J, Leclercq, B, Ghosn, M, Couanet, D, Ostronoff, M, Culine, S, Misset, Benoît, Escudier, B |
| المصدر: | Supportive Care in Cancer, 2 (4), 253-8 (1994-07) |
| بيانات النشر: | Springer-Verlag, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Bacteremia, Cardiac Output/physiology, Cause of Death, Germinoma/complications, Germinoma/drug therapy, Germinoma/physiopathology, Germinoma/secondary, Humans, Kidney/drug effects, Kidney/physiopathology, Leukocytosis/etiology, Lung Neoplasms/pathology, Lung Neoplasms/secondary, Lymphatic Metastasis, Male, Mediastinal Neoplasms/pathology, Mediastinal Neoplasms/secondary, Prognosis, Prospective Studies, Pulmonary Fibrosis/etiology, Remission Induction, Respiratory Insufficiency/etiology, Risk Factors, Survival Rate, Vascular Resistance/physiology, Bulky mediastinum, Poor-prognosis germ-cell tumors, Pulmonary metastases, Respiratory distress, Supportive care, Oncology, Human health sciences, Anesthesia & intensive care, Sciences de la santé humaine, Anesthésie & soins intensifs |
| الوصف: | Among patients suffering from nonseminomatous germ-cell tumor, with a poor prognosis, a subset underwent respiratory failure and died very early in the course of their treatment. Between 1982 and 1989, 11 out of 56 such patients (20%) died within the first 5 weeks of chemotherapy. The clinical, radiological, biological and infectious characteristics of these patients were analyzed. Nine patients had extensive pulmonary metastases and the 2 others presented a bulky mediastinal mass with pleural effusion. All patients experienced acute respiratory distress during chemotherapy and underwent mechanical ventilation. All patients were febrile, and septicemia was documented in 7 cases. WHO grade 4 and grade 1-2 renal toxicities occurred in 3 and 4 patients respectively. There was no tumor lysis syndrome. All patients died within 35 days from the start of therapy; 4 were autopsied. These 11 patients represent a clinical entity, having what we called super-high-risk germ cell tumors. Early death is related to pulmonary distress within the first 5 weeks of therapy. The origin of the pulmonary distress is multifactorial: bulky disease of the chest, infection, and interstitial fibrosis. Immediate full-dose standard chemotherapy in association with intensive supportive care is recommended in the management of these patients. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | http://link.springer.com/content/pdf/10.1007/BF00365732.pdf; urn:issn:0941-4355; urn:issn:1433-7339 |
| DOI: | 10.1007/BF00365732 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/293473 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.293473 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/BF00365732 |
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