دورية أكاديمية
Early Castration in Horses Does Not Impact Osteoarticular Metabolism
| العنوان: | Early Castration in Horses Does Not Impact Osteoarticular Metabolism |
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| المؤلفون: | Rouge, Marion, Legendre, Florence, Elkhatib, Razan, Delalande, Christelle, Cognié, Juliette, Reigner, Fabrice, Barrière, Philippe, Deleuze, Stefan, Hanoux, Vincent, Galéra, Philippe, Bouraïma-Lelong, Hélène |
| المصدر: | International Journal of Molecular Sciences, 24 (23), 16778 (2023-11-26) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis, Life sciences, Veterinary medicine & animal health, Animal production & animal husbandry, Anatomy (cytology, histology, embryology...) & physiology, Sciences du vivant, Médecine vétérinaire & santé animale, Productions animales & zootechnie, Anatomie (cytologie, histologie, embryologie...) & physiologie |
| الوصف: | The castration of stallions is traditionally performed after puberty, at around the age of 2 years old. No studies have focused on the effects of early castration on osteoarticular metabolism. Thus, we aimed to compare early castration (3 days after birth) with traditional castration (18 months of age) in horses. Testosterone and estradiol levels were monitored from birth to 33 months in both groups. We quantified the levels of biomarkers of cartilage and bone anabolism (CPII and N-MID) and catabolism (CTX-I and CTX-II), as well as of osteoarthritis (HA and COMP) and inflammation (IL-6 and PGE2). We observed a lack of parallelism between testosterone and estradiol synthesis after birth and during puberty in both groups. The extra-gonadal synthesis of steroids was observed around the 28-month mark, regardless of the castration age. We found the expression of estrogen receptor (ESR1) in cartilage and bone, whereas androgen receptor (AR) expression appeared to be restricted to bone. Nevertheless, with respect to osteoarticular metabolism, steroid hormone deprivation resulting from early castration had no discernable impact on the levels of biomarkers related to bone and cartilage metabolism, nor on those associated with OA and inflammation. Consequently, our research demonstrated that early castration does not disrupt bone and cartilage homeostasis. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | https://www.mdpi.com/1422-0067/24/23/16778/pdf; 10.3390/ijms242316778; urn:issn:1661-6596; urn:issn:1422-0067 |
| DOI: | 10.3390/ijms242316778 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/309368 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.309368 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.3390/ijms242316778 |
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