دورية أكاديمية
Does Chemotherapy-Induced Liver Injury Impair Postoperative Outcomes After Laparoscopic Liver Resection for Colorectal Metastases?
| العنوان: | Does Chemotherapy-Induced Liver Injury Impair Postoperative Outcomes After Laparoscopic Liver Resection for Colorectal Metastases? |
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| المؤلفون: | Neuberg, Maud, Triantafyllidis, Ioannis, Lefevre, Marine, Bennamoun, Mostefa, Sarran, Anthony, Beaussier, Marc, Louvet, Christophe, Gayet, Brice, Fuks, David |
| المصدر: | Journal of Gastrointestinal Surgery, 25 (5), 1203 - 1211 (2021-05) |
| بيانات النشر: | Springer, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | CALI, Chemotherapy, Colorectal liver metastases, Laparoscopic liver resection, Postoperative outcomes, Antineoplastic Agents, Hepatectomy/adverse effects, Humans, Liver, Retrospective Studies, Antineoplastic Agents/therapeutic use, Colorectal Neoplasms/surgery, Laparoscopy, Liver Neoplasms/drug therapy, Liver Neoplasms/surgery, Colorectal Neoplasms, Hepatectomy, Liver Neoplasms, Surgery, Gastroenterology, Human health sciences, Sciences de la santé humaine, Chirurgie |
| الوصف: | [en] BACKGROUND: Chemotherapy-associated liver injuries (CALI) have been associated with poor postoperative outcome after open liver resection. To date, no data concerning any correlation of CALI and laparoscopic liver resection (LLR) are available. In the present study, we evaluated the impact of CALI on short-term outcomes in patients undergoing LLR.MATERIALS AND METHODS: All patients who underwent in our department LLR for colorectal liver metastases (CRLM) from 2000 to 2016 were retrospectively reviewed. Patients were divided in 4 groups according to their pathological histology. In group 1 patients had normal liver parenchyma. Group 2 included patients with steatosis and steatohepatitis. Patients with sinusoidal obstruction syndrome (SOS) and nodular regenerative hyperplasia (NRH) were allocated to group 3, whereas the remaining with fibrosis and cirrhosis, were assigned to group 4.RESULTS: A total of 490 LLR for CRLM were included in the study. Perioperative details and morbidity did not differ significantly between the four groups. Subgroup analysis showed that NRH was associated with higher amount of blood loss (p = 0.043), overall (p = 0.021) and liver-specific morbidity (p = 0.039).CONCLUSION: NRH is a severe form of CALI that may worsen the short-term outcomes of patients undergoing LLR for CRLM. However, the remaining forms of CALI do not have a significant impact on perioperative outcomes after LLR. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | https://link.springer.com/content/pdf/10.1007/s11605-020-04636-0.pdf; urn:issn:1091-255X; urn:issn:1873-4626 |
| DOI: | 10.1007/s11605-020-04636-0 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/317020 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.317020 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/s11605-020-04636-0 |
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