دورية أكاديمية
Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure
| العنوان: | Interaction between dendritic cells and nerve fibres in lymphoid organs after oral scrapie exposure |
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| المؤلفون: | Dorban, Gauthier, Defaweux, Valérie, Demonceau, Christine, Flandroy, Sylvain, Van Lerberghe, Pierre-Bernard, Falisse-Poirier, Nandini, Piret, Joëlle, Heinen, Ernst, Antoine, Nadine |
| المصدر: | Virchows Archiv, 451 (6), 1057-1065 (2007-12) |
| بيانات النشر: | Springer, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | prion, dendritic cells, innervation, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Veterinary medicine & animal health, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie, Médecine vétérinaire & santé animale |
| الوصف: | In transmissible spongiform encephalopathies (TSEs), the infectious agent, called PrPsc, an abnormal isoform of the cellular prion protein, accumulates and replicates in lymphoid organs before affecting the nervous system. To clarify the cellular requirements for the neuro-invasion of the scrapie agent from the lymphoid organs to the central nervous system, we have studied, by confocal microscopy, the innervations within Peyer's patches, mesenteric lymph nodes and the spleen of mice in physiological conditions and after oral exposure to prion. Contacts between nerve fibres and PrPsc-associated cells, dendritic cells (DCs) and follicular dendritic cells (FDCs), were evaluated in preclinical prion-infected mice. Using a double immunolabelling strategy, we demonstrated the lack of innervation of PrPsc-accumulating cells (FDCs). Contacts between nerve fibers and PrPsc-propagating cells (DCs) were detected in T-cell zones and cell-trafficking areas. This supports, for the first time, the possible implication of dendritic cells in the prion neuroinvasion process. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | urn:issn:0945-6317; urn:issn:1432-2307 |
| DOI: | 10.1007/s00428-007-0476-6 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/7117 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.7117 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1007/s00428-007-0476-6 |
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