دورية أكاديمية
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
| العنوان: | Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors |
|---|---|
| المؤلفون: | Li, X. R., Tjwa, M., Moons, L., Fons, P., Noël, Agnès, Ny, A., Zhou, J. M., Lennartsson, J., Li, H., Luttun, A., Ponten, A., Devy, L., Bouche, A., Oh, H., Manderveld, A., Blacher, Silvia, Communi, D., Savi, P., Bono, F., Dewerchin, M., Foidart, Jean-Michel, Autiero, M., Herbert, J. M., Collen, D., Heldin, C. H., Eriksson, U., Carmeliet, P. |
| المصدر: | Journal of Clinical Investigation, 115 (1), 118-127 (2005-01) |
| بيانات النشر: | American Society for Clinical Investigation, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Human health sciences, Laboratory medicine & medical technology, Sciences de la santé humaine, Médecine de laboratoire & technologie médicale |
| الوصف: | The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| DOI: | 10.1172/JCI19189 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/9687 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.9687 |
| قاعدة البيانات: | ORBi |
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