التفاصيل البيبلوغرافية
| العنوان: |
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes |
| المؤلفون: |
Jill C. Milne, Philip D. Lambert, Simon Schenk, David P. Carney, Jesse J. Smith, David J. Gagne, Lei Jin, Olivier Boss, Robert B. Perni, Chi B. Vu, Jean E. Bemis, Roger Xie, Jeremy S. Disc |
| المصدر: |
Nature, Nature. 450(7170):712-716 |
| سنة النشر: |
2007 |
| الوصف: |
SIRT1 activators in diabetes SIRT1, an NAD+-dependent deacetylase that acts on proteins involved in cellular regulation, has been implicated in longevity and as a mediator of the beneficial effects of calorie restriction. A new screening programme has identified a series of small-molecule SIRT1 activators that are structurally unlike, and 1,000-fold more potent than, resveratrol, the well-known SIRT1 activator found in red wine. These new compounds improve metabolic function in animal models of diabetes and obesity, suggesting that they may have therapeutic potential in type 2 diabetes and insulin resistance. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/nature06261 |
| الإتاحة: |
https://ideas.repec.org/a/nat/nature/v450y2007i7170d10.1038_nature06261.html |
| رقم الأكسشن: |
edsrep.a.nat.nature.v450y2007i7170d10.1038.nature06261 |
| قاعدة البيانات: |
RePEc |
