التفاصيل البيبلوغرافية
العنوان: |
Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis |
المؤلفون: |
Jack Twilton, Mathew R. Johnson, Vinayak Sidana, Mareena C. Franke, Cecilia Bottecchia, Dan Lehnherr, François Lévesque, Spring M. M. Knapp, Luning Wang, James B. Gerken, Cynthia M. Hong, T |
المصدر: |
Nature, Nature. 623(7985):71-76 |
سنة النشر: |
2023 |
الوصف: |
Electrochemical synthesis can provide more sustainable routes to industrial chemicals1–3. Electrosynthetic oxidations may often be performed ‘reagent-free’, generating hydrogen (H2) derived from the substrate as the sole by-product at the counter electrode. Electrosynthetic reductions, however, require an external source of electrons. Sacrificial metal anodes are commonly used for small-scale applications4, but more sustainable options are needed at larger scale. Anodic water oxidation is an especially appealing option1,5,6, but many reductions require anhydrous, air-free reaction conditions. In such cases, H2 represents an ideal alternative, motivating the growing interest in the electrochemical hydrogen oxidation reaction (HOR) under non-aqueous conditions7–12. Here we report a mediated H2 anode that achieves indirect electrochemical oxidation of H2 by pairing thermal catalytic hydrogenation of an anthraquinone mediator with electrochemical oxidation of the anthrahydroquinone. This quinone-mediated H2 anode is used to support nickel-catalysed cross-electrophile coupling (XEC), a reaction class gaining widespread adoption in the pharmaceutical industry13–15. Initial validation of this method in small-scale batch reactions is followed by adaptation to a recirculating flow reactor that enables hectogram-scale synthesis of a pharmaceutical intermediate. The mediated H2 anode technology disclosed here offers a general strategy to support H2-driven electrosynthetic reductions. |
نوع الوثيقة: |
redif-article |
اللغة: |
English |
DOI: |
10.1038/s41586-023-06534 |
الإتاحة: |
https://ideas.repec.org/a/nat/nature/v623y2023i7985d10.1038_s41586-023-06534-2.html |
رقم الأكسشن: |
edsrep.a.nat.nature.v623y2023i7985d10.1038.s41586.023.06534.2 |
قاعدة البيانات: |
RePEc |