دورية أكاديمية

Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis

التفاصيل البيبلوغرافية
العنوان: Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis
المؤلفون: Jack Twilton, Mathew R. Johnson, Vinayak Sidana, Mareena C. Franke, Cecilia Bottecchia, Dan Lehnherr, François Lévesque, Spring M. M. Knapp, Luning Wang, James B. Gerken, Cynthia M. Hong, T
المصدر: Nature, Nature. 623(7985):71-76
سنة النشر: 2023
الوصف: Electrochemical synthesis can provide more sustainable routes to industrial chemicals1–3. Electrosynthetic oxidations may often be performed ‘reagent-free’, generating hydrogen (H2) derived from the substrate as the sole by-product at the counter electrode. Electrosynthetic reductions, however, require an external source of electrons. Sacrificial metal anodes are commonly used for small-scale applications4, but more sustainable options are needed at larger scale. Anodic water oxidation is an especially appealing option1,5,6, but many reductions require anhydrous, air-free reaction conditions. In such cases, H2 represents an ideal alternative, motivating the growing interest in the electrochemical hydrogen oxidation reaction (HOR) under non-aqueous conditions7–12. Here we report a mediated H2 anode that achieves indirect electrochemical oxidation of H2 by pairing thermal catalytic hydrogenation of an anthraquinone mediator with electrochemical oxidation of the anthrahydroquinone. This quinone-mediated H2 anode is used to support nickel-catalysed cross-electrophile coupling (XEC), a reaction class gaining widespread adoption in the pharmaceutical industry13–15. Initial validation of this method in small-scale batch reactions is followed by adaptation to a recirculating flow reactor that enables hectogram-scale synthesis of a pharmaceutical intermediate. The mediated H2 anode technology disclosed here offers a general strategy to support H2-driven electrosynthetic reductions.
نوع الوثيقة: redif-article
اللغة: English
DOI: 10.1038/s41586-023-06534
الإتاحة: https://ideas.repec.org/a/nat/nature/v623y2023i7985d10.1038_s41586-023-06534-2.html
رقم الأكسشن: edsrep.a.nat.nature.v623y2023i7985d10.1038.s41586.023.06534.2
قاعدة البيانات: RePEc
الوصف
DOI:10.1038/s41586-023-06534