دورية أكاديمية
PRAME gene expression profile in medulloblastoma
العنوان: | PRAME gene expression profile in medulloblastoma |
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المؤلفون: | Vulcani-Freitas, Tânia Maria, Saba-Silva, Nasjla, Cappellano, Andréa, Cavalheiro, Sérgio, Toledo, Sílvia Regina Caminada de |
المصدر: | Arquivos de Neuro-Psiquiatria. February 2011 69(1) |
بيانات النشر: | Academia Brasileira de Neurologia - ABNEURO, 2011. |
سنة النشر: | 2011 |
مصطلحات موضوعية: | PRAME, gene expression, medulloblastoma, immunotherapy |
الوصف: | Medulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an ideal vaccine target for tumor immunotherapy. In order to find a potential molecular target, we investigated PRAME expression in medulloblastoma fragments and we compare the results with the clinical features of each patient. Analysis of gene expression was performed by real-time quantitative PCR from 37 tumor samples. The Mann-Whitney test was used to analysis the relationship between gene expression and clinical characteristics. Kaplan-Meier curves were used to evaluate survival. PRAME was overexpressed in 84% samples. But no statistical association was found between clinical features and PRAME overexpression. Despite that PRAME gene could be a strong candidate for immunotherapy since it is highly expressed in medulloblastomas. |
نوع الوثيقة: | article |
وصف الملف: | text/html |
اللغة: | English |
تدمد: | 0004-282X |
DOI: | 10.1590/S0004-282X2011000100003 |
URL الوصول: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000100003 |
حقوق: | info:eu-repo/semantics/openAccess |
رقم الأكسشن: | edssci.S0004.282X2011000100003 |
قاعدة البيانات: | SciELO |
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