Synthesis of 2,4-disubstituted thiazole combinatorial unit on solid-phase: microwave assisted conversion of alcohol to amine monitored by FT-IR
| العنوان: | Synthesis of 2,4-disubstituted thiazole combinatorial unit on solid-phase: microwave assisted conversion of alcohol to amine monitored by FT-IR |
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| المؤلفون: | Antonow, Dyeison, Mahler, S. Graciela, Serra, Gloria L., Manta, Eduardo, Eifler-Lima, Vera Lucia |
| المصدر: | Journal of the Brazilian Chemical Society. June 2005 16(3a) |
| بيانات النشر: | Sociedade Brasileira de Química, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | thiazole, microwave, monitoring solid-phase reactions |
| الوصف: | Microwave-assisted solid-phase synthesis of the 2,4-disubstituted thiazole 3 on Merrifield Resin is described. The hydroxyl moiety was converted to amine in five steps - including coupling and cleavage - within a total reaction time of 2 hours and 26% overall yield. The entire solid-phase synthesis was efficiently monitored by FT-IR/KBr pellets and allows potential use in combinatorial chemistry. |
| نوع الوثيقة: | other |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0103-5053 |
| DOI: | 10.1590/S0103-50532005000300023 |
| URL الوصول: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000300023 |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edssci.S0103.50532005000300023 |
| قاعدة البيانات: | SciELO |
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