A Restricted Role for FcγR in the Regulation of Adaptive Immunity
| العنوان: | A Restricted Role for FcγR in the Regulation of Adaptive Immunity |
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| المؤلفون: | Fransen, Marieke F, Nandakumar, Kutty Selva, 1965 |
| المصدر: | Journal of Immunology. 200(8):2615-2626 |
| الوصف: | By their interaction with IgG immune complexes, FcγR and complement link innate and adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG downstream effector functions are often impaired, as well as adaptive immunity. Based on a variety of model systems using FcγR-knockout mice, it has been concluded that FcγRs are also key regulators of innate and adaptive immunity; however, several of the model systems underpinning these conclusions suffer from flawed experimental design. To address this issue, we generated a novel mouse model deficient for all FcγRs (FcγRI/II/III/IV-/- mice). These mice displayed normal development and lymphoid and myeloid ontogeny. Although IgG effector pathways were impaired, adaptive immune responses to a variety of challenges, including bacterial infection and IgG immune complexes, were not. Like FcγRIIb-deficient mice, FcγRI/II/III/IV-/- mice developed higher Ab titers but no autoantibodies. These observations indicate a redundant role for activating FcγRs in the modulation of the adaptive immune response in vivo. We conclude that FcγRs are downstream IgG effector molecules with a restricted role in the ontogeny and maintenance of the immune system, as well as the regulation of adaptive immunity. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48391 https://doi.org/10.4049/jimmunol.1700429 https://hh.diva-portal.org/smash/get/diva2:1703111/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 00221767 15506606 |
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| DOI: | 10.4049/jimmunol.1700429 |