An assessment framework including a set of impact categories, criteria, and indicators was created in order to analyse a broad set of factors affecting the feasibility of Negative Emission Technologies (NETs). Each criterion was addressed in terms of the best available literature. The analysis has shown clearly that uncertainties surrounding NETs are significant, publications use a variety of metrics and assumptions which complicates comparison between studies and that the feasibility of individual NETs varies significantly depending on national or regional context. Further top-down assessments of NETs will do little to satisfy the need to understand the difference between the technical potentials and practical feasibility of individual NETs. Regional bottom-up studies are needed, focusing on the potential to deliver on sustainable development objectives to better understand potentials in real-world conditions.