Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women
| العنوان: | Mild impairment of renal function (shrunken pore syndrome) is associated with increased risk of a future first-ever myocardial infarction in women |
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| المؤلفون: | Söderström, Elisabet, Blind, Ravna, Wennberg, Patrik, 1972, Andersson, Jonas, 1977, Söderberg, Stefan, Nilsson, Torbjörn K., Hultdin, Johan |
| المصدر: | Scandinavian Journal of Clinical and Laboratory Investigation. 81(6):438-445 |
| مصطلحات موضوعية: | Myocardial infarction, creatinine, cystatin C, glomerular filtration rate, chronic renal insufficiency, shrunken pore syndrome |
| الوصف: | Impaired renal function is associated both with the development of cardiovascular disease and its prognosis. A new syndrome called ' Shrunken Pore Syndrome ' has been suggested, as the estimated glomerular filtration rate for cystatin C (eGFR(cystatin C)) is affected earlier due to differences in molecular size compared to eGFR(creatinine). The aim was to investigate if a lower eGFR(cystatin C)/eGFR(creatinine) ratio in a prospective setting increases the risk of later developing a first-ever myocardial infarction (MI) independently of other cardiovascular risk factors. We used a nested case-referent study design within the Northern Sweden Health and Disease Study, and 545 subjects (29.0% women) were identified who prospectively developed a first-ever MI, and their 1054 matched referents. For women, but not for men, one standard deviation (SD) increase of ln z-scores of eGFR(cystatin C)/eGFR(creatinine) ratio was associated with a lower risk of a future MI: odds ratio [95% confidence interval] 0.58 [0.34-0.99], adjusted for apolipoprotein B/A1 ratio, CRP, homocysteine, systolic blood pressure, body mass index, and diabetes. Furthermore, a high eGFR(creatinine) associated independently with an increased risk of future MI in men only: OR 1.25 [1.05-1.48]. Thus, for women, a lower eGFR(cystatin C)/eGFR(creatinine) ratio is associated with a higher risk of having a future first-ever MI, and it may be a valuable, easily implemented biomarker for risk of cardiovascular disease. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187367 https://doi.org/10.1080/00365513.2021.1941235 https://umu.diva-portal.org/smash/get/diva2:1592920/FULLTEXT02.pdf |
| قاعدة البيانات: | SwePub |
PDF full text from Publisher | تدمد: | 00365513 |
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| DOI: | 10.1080/00365513.2021.1941235 |