Bone without borders - Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope
| العنوان: | Bone without borders - Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope |
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| المؤلفون: | Shah, Furqan A., Jolic, Martina, Micheletti, Chiara, Omar, Omar, Norlindh, Birgitta, Emanuelsson, Lena, Engqvist, Håkan, 1972, Engstrand, Thomas, Palmquist, Anders, Thomsen, Peter |
| المصدر: | BIOACTIVE MATERIALS. 19:103-114 |
| مصطلحات موضوعية: | Bone, Calcium phosphate, Monetite, Calcium pyrophosphate, Electron microscopy, Raman spectroscopy |
| الوصف: | Calcium phosphates (CaP) represent an important class of osteoconductive and osteoinductive biomaterials. As proof-of-concept, we show how a multi-component CaP formulation (monetite, beta-tricalcium phosphate, and calcium pyrophosphate) guides osteogenesis beyond the physiological envelope. In a sheep model, hollow dome-shaped constructs were placed directly over the occipital bone. At 12 months, large amounts of bone (similar to 75%) occupy the hollow space with strong evidence of ongoing remodelling. Features of both compact bone (osteonal/osteon-like arrangements) and spongy bone (trabeculae separated by marrow cavities) reveal insights into function/need-driven microstructural adaptation. Pores within the CaP also contain both woven bone and vascularised lamellar bone. Osteoclasts actively contribute to CaP degradation/removal. Of the constituent phases, only calcium pyrophosphate persists within osseous (cutting cones) and non-osseous (macrophages) sites. From a translational perspective, this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474363 https://doi.org/10.1016/j.bioactmat.2022.03.012 https://uu.diva-portal.org/smash/get/diva2:1658109/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| DOI: | 10.1016/j.bioactmat.2022.03.012 |
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