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Involvement of platelet-derived growth factor in disease: development of specific antagonists

التفاصيل البيبلوغرافية
العنوان: Involvement of platelet-derived growth factor in disease: development of specific antagonists
المؤلفون: Östman, Arne, Heldin, Carl-Henrik
المصدر: Advances in Cancer Research. 80:1-38
مصطلحات موضوعية: Animals, Arteriosclerosis/drug therapy/metabolism, Fibrosis/drug therapy/metabolism, Glomerulonephritis/drug therapy/metabolism, Humans, Lung Diseases/drug therapy/metabolism, Neoplasms/drug therapy/metabolism, Platelet-Derived Growth Factor/*antagonists & inhibitors/chemistry/*metabolism, Protein Structure, Tertiary, Receptors, Platelet-Derived Growth Factor/chemistry/metabolism, Signal Transduction
الوصف: Platelet-derived growth factor (PDGF) is a family of dimeric isoforms that stimulates, e.g., growth, chemotaxis and cell shape changes of various connective tissue cell types and certain other cells. The cellular effects of PDGF isoforms are exerted through binding to two structurally related tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation. This enables a number of SH2 domain containing signal transduction molecules to bind to the receptors, thereby initiating various signaling pathways. PDGF isoforms have important roles during the embryonic development, particularly in the formation of connective tissue in various organs. In the adult, PDGF stimulates wound healing. Overactivity of PDGF has been implicated in certain disorders, including fibrotic conditions, atherosclerosis, and malignancies. Different kinds of PDGF antagonists are currently being developed and evaluated in different animal disease models, as well as in clinical trials.
وصف الملف: print
URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73368
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11034538&dopt=Citation
قاعدة البيانات: SwePub
الوصف
تدمد:0065230X
21625557
DOI:10.1016/S0065-230X(01)80010-5