دورية أكاديمية
Genotype and Phenotype of Caffeine Metabolism: A Biochemistry Laboratory Experiment
| العنوان: | Genotype and Phenotype of Caffeine Metabolism: A Biochemistry Laboratory Experiment |
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| اللغة: | English |
| المؤلفون: | Millard, Julie T. (ORCID |
| المصدر: | Journal of Chemical Education. Oct 2018 95(10):1856-1860. |
| الإتاحة: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 5 |
| تاريخ النشر: | 2018 |
| نوع الوثيقة: | Journal Articles Reports - Descriptive |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Science Instruction, College Science, Undergraduate Study, Biochemistry, Science Laboratories, Genetics, Metabolism, Drug Use, Science Experiments, Laboratory Experiments |
| DOI: | 10.1021/acs.jchemed.8b00318 |
| تدمد: | 0021-9584 |
| مستخلص: | An experiment for the upper-division undergraduate biochemistry laboratory is described in which students investigate the influence of genetic variations of cytochrome P450 1A2 on drug metabolism, using caffeine as a model compound. Saliva samples from human subjects are characterized for a single-nucleotide polymorphism in the CYP1A2 gene (genotyping) and for the rate of caffeine clearance (phenotyping). This experiment has clinical significance in the area of personalized medicine. |
| Abstractor: | As Provided |
| Entry Date: | 2018 |
| رقم الأكسشن: | EJ1195628 |
| قاعدة البيانات: | ERIC |
Find this issue from the American Chemical Society | تدمد: | 0021-9584 |
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| DOI: | 10.1021/acs.jchemed.8b00318 |