دورية أكاديمية
An Examination of Cognitive Heterogeneity in Parkinson Disease: The Dual-Syndrome Hypothesis
| العنوان: | An Examination of Cognitive Heterogeneity in Parkinson Disease: The Dual-Syndrome Hypothesis |
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| اللغة: | English |
| المؤلفون: | Dale Summers (ORCID |
| المصدر: | Journal of Speech, Language, and Hearing Research. 2024 67(4):1127-1135. |
| الإتاحة: | American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org |
| Peer Reviewed: | Y |
| Page Count: | 9 |
| تاريخ النشر: | 2024 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Neurological Impairments, Cognitive Ability, Symptoms (Individual Disorders), Risk, Dementia, Individual Characteristics, Brain Hemisphere Functions |
| DOI: | 10.1044/2024_JSLHR-23-00621 |
| تدمد: | 1092-4388 1558-9102 |
| مستخلص: | Purpose: Cognitive impairment is one of the most debilitating nonmotor symptoms in Parkinson disease (PD), and its presentation is heterogeneous. One proposed model to explain cognitive variability in PD is the dual-syndrome hypothesis. This hypothesis delineates two cognitive profiles, a "fronto-striatal" profile and a "posterior cortical" profile according to symptom presentation, associated motor phenotype, and risk for dementia. The current study examined the dual-syndrome hypothesis in individuals with idiopathic PD to evaluate the existence of these profiles, determine the association with the motor phenotype (tremor dominant vs. postural instability/gait disorder), and assess the relative risk for dementia. Method: A retrospective examination was conducted using data from the Parkinson's Progression Markers Initiative database at baseline (within 2 years of diagnosis) and 5 years after baseline. Descriptive categorizations, cluster analyses, generalized linear mixed models, and logistic regressions were used to address the research questions. Results: There was emerging evidence of cognitive profiles; however, these were not fully supported by cluster analyses. Baseline cognitive profile was associated with later motor phenotype, and as predicted, dementia risk was greatest in persons with baseline posterior cortical impairments. Conclusion: The current results provide mixed support for the dual-syndrome hypothesis, with some evidence that the posterior cortical cognitive profile is associated with postural instability and gait disorder as well as greater dementia risk. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| رقم الأكسشن: | EJ1421040 |
| قاعدة البيانات: | ERIC |
| تدمد: | 1092-4388 1558-9102 |
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| DOI: | 10.1044/2024_JSLHR-23-00621 |