دورية أكاديمية
Effects of GABA[subscript A] Modulators on the Repeated Acquisition of Response Sequences in Squirrel Monkeys
| العنوان: | Effects of GABA[subscript A] Modulators on the Repeated Acquisition of Response Sequences in Squirrel Monkeys |
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| اللغة: | English |
| المؤلفون: | Campbell, Una C., Winsauer, Peter J., Stevenson, Michael W. |
| المصدر: | Journal of the Experimental Analysis of Behavior. Jul 2004 82(1):37-56. |
| الإتاحة: | Society for the Experimental Analysis of Behavior. Available from: Indiana University Department of Psychology. Bloomington, IN 47405. Tel: 812-334-0395; Fax: 812-855-4691; e-mail: jeab@indiana.edu; Web site: http://seab.envmed.rochester.edu/jeab/index.html |
| Peer Reviewed: | Y |
| وصف مادي: | |
| Page Count: | 20 |
| تاريخ النشر: | 2004 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| Descriptors: | Accuracy, Language Acquisition, Multivariate Analysis, Animals, Animal Behavior, Behavioral Science Research, Food, Reinforcement, Light, Color, Visual Stimuli, Error Patterns, Responses, Drug Use |
| تدمد: | 0022-5002 |
| مستخلص: | The present study investigated the effects of positive and negative GABA[subscript A] modulators under three different baselines of repeated acquisition in squirrel monkeys in which the monkeys acquired a three-response sequence on three keys under a second-order fixed-ratio (FR) schedule of food reinforcement. In two of these baselines, the second-order FR schedule and the discriminative stimuli for the response sequence were manipulated ("chain-strained" and "tandem-strained"). In the third baseline condition, response-independent tail shock was presented during acquisition of the response sequence. All of these baselines maintained high error levels and produced slow rates of acquisition. Under both the chain-strained and tandem-strained conditions, the positive GABA[subscript A] modulator triazolam (0.0032-0.1 mg/kg) and the negative GABA[subscript A] modulators [beta]-CCE (ethyl-[beta]-carboline-3-carboxylate; 0.01-1 mg/kg), [beta]-CCM (methyl-[beta]-carboline-3-carboxylate; 0.0032-0.1 mg/kg), and FG-7142 (methyl-[beta]-carboline-3-carboxamide; 0.18-10 mg/kg) dose-dependently decreased overall response rate compared to administration of saline (control). Under the same two conditions, triazolam and the negative GABA[subscript A] modulators also increased the percentage of errors; however, the effects on accuracy frequently depended on the baseline condition and the particular modulator. In contrast, triazolam only decreased errors and enhanced acquisition in the presence of concurrent response-independent tail shock when compared to saline administration under this condition. The neutral GABA[subscript A] modulator, flumazenil (1 mg/kg), had no effect on rate or accuracy of responding when administered alone, but antagonized the rate-decreasing and error-increasing effects produced by the negative GABA[subscript A] modulators. Together, these data suggest that the effects of both the positive and negative GABA[subscript A] modulators on acquisition can be similar in squirrel monkeys (i.e., both types of modulator may produce rate-decreasing and error-increasing effects) and that their effects on acquisition depend, in part, on the environmental conditions maintaining acquisition. (Contains 9 figures.) |
| Abstractor: | As Provided |
| Number of References: | 47 |
| Entry Date: | 2013 |
| URL الوصول: | http://seab.envmed.rochester.edu/jeab/toc/2004/jeabjul04.shtml |
| رقم الأكسشن: | EJ997363 |
| قاعدة البيانات: | ERIC |
Full Text Finder | تدمد: | 0022-5002 |
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