التفاصيل البيبلوغرافية
| العنوان: |
Scedosporium apiospermum sinusitis after bone marrow transplantation: report of a case. |
| المؤلفون: |
Machado CM; Mycology Laboratory, Instituto de Medicina Tropical de São Paulo, Brasil., Martins MA, Heins-Vaccari EM, Lacaz Cda S, Macedo MC, Castelli JB, Medeiros RS, Silva RL, Dulley FL |
| المصدر: |
Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 1998 Sep-Oct; Vol. 40 (5), pp. 321-3. |
| نوع المنشور: |
Case Reports; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: Print Cited Medium: Print ISSN: 0036-4665 (Print) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo |
| مواضيع طبية MeSH: |
Bone Marrow Transplantation* , Pseudallescheria*, Dermatomycoses/*diagnosis , Sinusitis/*microbiology, Adult ; Fatal Outcome ; Graft vs Host Disease/complications ; Humans ; Male ; Postoperative Complications |
| مستخلص: |
A forty-year-old man underwent an allogeneic BMT from his HLA identical sister. GvHD prophylaxis was done with cyclosporine (CyA), methotrexate and prednisone (PDN). On day +90 extensive GvHD was noted and higher doses of immunosuppressive drugs alternating CyA with PDN were initiated. Patient's follow-up was complicated by intermittent episodes of leukopenia and monthly episodes of sinusitis or pneumonia. One year after BMT, the patient developed hoarseness and nasal voice. No etiologic agent could be identified on a biopsy sample of the vocal chord. Upon tapering the doses of immunosuppressive drugs, the patient had worsening of chronic GvHD and was reintroduced on high doses of cyclosporine alternating with prednisone on day +550. Three months later, GvHD remained out of control and the patient was started on azathioprine. On day +700, hoarseness and nasal voice recurred. Another biopsy of the left vocal chord failed to demonstrate infection. Episodes of sinusitis became more frequent and azathioprine was withheld 3 months after it was started. One month later, the patient had bloody nasal discharge and surgical drainage of maxillary sinuses was performed. Histopathology showed hyphae and cultures grew Scedosporium apiospermum. Itraconazole 800 mg/day was initiated. The patient developed progressive respiratory failure and died 15 days later. |
| تواريخ الأحداث: |
Date Created: 19990225 Date Completed: 19990504 Latest Revision: 20190607 |
| رمز التحديث: |
20240627 |
| DOI: |
10.1590/s0036-46651998000500010 |
| PMID: |
10030078 |
| قاعدة البيانات: |
MEDLINE |
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