دورية أكاديمية
Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospital.
| العنوان: | Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospital. |
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| المؤلفون: | Sloos JH; Department of Medical Microbiology, Leiden University Medical Center, The Netherlands., van de Klundert JA, Dijkshoorn L, van Boven CP |
| المصدر: | The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1998 Dec; Vol. 42 (6), pp. 787-91. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Print ISSN: 0305-7453 (Print) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1997- : London : Oxford University Press Original Publication: London, New York, Academic Press. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Coagulase/*metabolism , Staphylococcal Infections/*microbiology , Staphylococcus/*drug effects , Staphylococcus/*enzymology , Teicoplanin/*pharmacology, Drug Resistance, Microbial ; Hospitals, Teaching ; Humans ; Microbial Sensitivity Tests ; Staphylococcus/isolation & purification ; Staphylococcus epidermidis/drug effects ; Staphylococcus epidermidis/enzymology ; Staphylococcus epidermidis/isolation & purification ; Vancomycin/pharmacology |
| مستخلص: | The susceptibility of two collections of coagulase-negative staphylococci (CNS) isolated from clinical specimens for teicoplanin and vancomycin were compared. They comprised 91 and 101 isolates, collected in 1985 and 1994 respectively, from different departments of a teaching hospital. MICs of vancomycin and teicoplanin were determined by a modified Etest method. Additionally, a disc diffusion test was performed for teicoplanin. All isolates were susceptible to vancomycin (MIC < or = 4 mg/L). Two of the 91 isolates collected in 1985 were intermediate to teicoplanin (MIC between 8 and 32 mg/L), whereas in 1994 the number of intermediate isolates was 20 out of 101 (P < 0.01). The correlation between MICs, as determined by the modified Etest assay, and disc diffusion zones was poor (r = -0.35). Results show that resistance to teicoplanin in CNS has increased in the study hospital over a period of 9 years. This increase is likely to be correlated with the introduction of teicoplanin. Furthermore, a disc diffusion method does not appear to be the first method of choice for detection of strains of CNS with diminished susceptibility to teicoplanin. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Coagulase) 61036-62-2 (Teicoplanin) 6Q205EH1VU (Vancomycin) |
| تواريخ الأحداث: | Date Created: 19990303 Date Completed: 19990809 Latest Revision: 20190513 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1093/jac/42.6.787 |
| PMID: | 10052903 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0305-7453 |
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| DOI: | 10.1093/jac/42.6.787 |