التفاصيل البيبلوغرافية
| العنوان: |
Coping with stress in rats and mice: differential peptidergic modulation of the amygdala-lateral septum complex. |
| المؤلفون: |
Koolhaas JM; Department of Animal Physiology, Haren, The Netherlands., Everts H, de Ruiter AJ, de Boer SF, Bohus B |
| المصدر: |
Progress in brain research [Prog Brain Res] 1998; Vol. 119, pp. 437-48. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376441 Publication Model: Print Cited Medium: Print ISSN: 0079-6123 (Print) Linking ISSN: 00796123 NLM ISO Abbreviation: Prog Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: |
Adaptation, Psychological/*physiology , Amygdala/*metabolism , Septal Nuclei/*metabolism , Stress, Physiological/*metabolism , Vasopressins/*metabolism, Aggression/physiology ; Animals ; Male ; Mice ; Rats |
| مستخلص: |
This chapter focuses on the parvicellular vasopressin (VP) system originating from the medial nucleus of the amygdala (MeA) and bed nucleus of the stria terminalis (BNST). The vasopressinergic fibers of these nuclei innervate a number of limbic brain areas including the septum-hippocampal complex. Interestingly, this VP system is sexually dimorphic and the VP synthesis in this system depends on circulating gonadal steroids. Studies in rats and mice show that the variation in the lateral septal VP network within the male gender is as large as the variation between the sexes as reported in the literature. Non-aggressive males are characterized by a far more extensive VP network and a higher VP content in the lateral septal area than aggressive males. A review of the literature on the function of lateral septal VP in the organization of behavior reveals not only a modulatory role of behavior in a social context, but also of fear- and anxiety-related behaviors. It is argued that these seemingly diverse functions might be explained by the concept of coping style. Extensive behavioral and physiological analyses in a variety of animal species show that males may be characterized by the way in which they cope with environmental challenges in general. Aggressive males tend to cope actively with their environment whereas non-aggressive males seem to accept the situation as it is more easily. In several tests, we determined the effects of chronic infusion of the V1 receptor antagonist locally into the lateral septal area in male rats. The main conclusion from these experiments is that LS VP does not modulate coping style in general. However, the experiments confirm the idea that LS VP has a certain degree of functional specificity in social behavior and social learning tasks. Together with the observation that the size and distribution of the vasopressinergic system may be highly variable between individual males in relation to their coping style, this suggests that the lateral septal vasopressinergic system is involved in the differential capacity of individuals to cope behaviorally with challenges of a social nature. |
| Number of References: |
68 |
| المشرفين على المادة: |
11000-17-2 (Vasopressins) |
| تواريخ الأحداث: |
Date Created: 19990313 Date Completed: 19990329 Latest Revision: 20190905 |
| رمز التحديث: |
20221213 |
| DOI: |
10.1016/s0079-6123(08)61586-1 |
| PMID: |
10074805 |
| قاعدة البيانات: |
MEDLINE |
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