دورية أكاديمية
Optimization and validation of chiral high-performance liquid chromatographic method for analysis of a fibrinogen (gpIIb/IIIa) receptor antagonist.
| العنوان: | Optimization and validation of chiral high-performance liquid chromatographic method for analysis of a fibrinogen (gpIIb/IIIa) receptor antagonist. |
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| المؤلفون: | Williams RC; DuPont Pharmaceuticals Company, Wilmington, DE 19880-0353, USA., Miyawa JH, Boucher RJ, Brockson RW |
| المصدر: | Journal of chromatography. A [J Chromatogr A] 1999 Jun 04; Vol. 844 (1-2), pp. 171-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print Cited Medium: Print ISSN: 0021-9673 (Print) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| مواضيع طبية MeSH: | Amidines/*analysis , Chromatography, High Pressure Liquid/*methods , Fibrinolytic Agents/*analysis , Isoxazoles/*analysis , Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors, Amidines/chemistry ; Isoxazoles/chemistry ; Orosomucoid ; Quality Control ; Sensitivity and Specificity ; Stereoisomerism |
| مستخلص: | A chiral HPLC separation on an alpha 1-acid glycoprotein (AGP) column was developed for the separation of roxifiban, a fibrinogen receptor antagonist, from its related chiral impurities. The proposed method was optimized for mobile phase buffer concentration, organic modifier, and temperature using experimental design. The method was then validated for use in release testing of the roxifiban drug substance. |
| المشرفين على المادة: | 0 (Amidines) 0 (Fibrinolytic Agents) 0 (Isoxazoles) 0 (Orosomucoid) 0 (Platelet Glycoprotein GPIIb-IIIa Complex) Q476FMZ72G (roxifiban) |
| تواريخ الأحداث: | Date Created: 19990710 Date Completed: 20000112 Latest Revision: 20190720 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0021-9673(99)00172-7 |
| PMID: | 10399330 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0021-9673 |
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| DOI: | 10.1016/s0021-9673(99)00172-7 |