دورية أكاديمية
Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease.
| العنوان: | Frequency of ovarian cysts in patients with autosomal dominant polycystic kidney disease. |
|---|---|
| المؤلفون: | Stamm ER; Departments of Medicine and Radiology, University of Colorado Health Sciences Center, Denver, CO, USA. e.stamm@uchsc.edu, Townsend RR, Johnson AM, Garg K, Manco-Johnson M, Gabow PA |
| المصدر: | American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 1999 Jul; Vol. 34 (1), pp. 120-4. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8110075 Publication Model: Print Cited Medium: Internet ISSN: 1523-6838 (Electronic) Linking ISSN: 02726386 NLM ISO Abbreviation: Am J Kidney Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : W.B. Saunders Original Publication: New York, N.Y. : Grune & Stratton, c1981- |
| مواضيع طبية MeSH: | Ovarian Cysts/*epidemiology , Polycystic Kidney, Autosomal Dominant/*genetics, Adult ; Case-Control Studies ; Databases, Factual ; Female ; Humans ; Incidence ; Ovarian Cysts/diagnostic imaging ; Polycystic Kidney, Autosomal Dominant/epidemiology ; Prospective Studies ; Retrospective Studies ; Ultrasonography |
| مستخلص: | Extrarenal cysts occur in patients with autosomal dominant polycystic kidney disease (ADPKD) most frequently in the liver. Ovarian cysts have been reported in women with ADPKD, but their frequency has not been determined. Therefore, we analyzed the historical data in our database of 337 women with ADPKD and 199 of their unaffected female family members (NADPKD). In addition, we prospectively studied 25 nonpregnant, premenopausal women with ADPKD and 25 nonpregnant, premenopausal, age-matched control women recruited from the general population to assess the occurrence of ovarian cysts. No women in either the control or ADPKD groups were receiving exogenous estrogen or progesterone. All women underwent sonographic examination using a 5- or 7.5-MHz vaginal probe. A normal ovarian follicle was defined as a fluid-filled structure less than 2 cm in average diameter, and an ovarian cyst as one of 2 cm or greater. From the historical data, 28% of the women with ADPKD gave a history of ovarian cysts compared with 18% of the NADPKD women (P < 0.05). In the prospective study, the mean age of the women with ADPKD was not different from that of the control women (40.9 +/- 1.2 v 39.3 +/- 1.2 years; P = not significant [NS]). There was no difference in frequency of normal follicles found in women with ADPKD or controls (80% v 96%; P = NS), nor was there a difference in the frequency of ovarian cysts found in women with ADPKD or controls (12% v 12%; P = NS). There was no difference in the calculated ovarian volumes between the women with ADPKD and controls (9.9 +/- 2. 5 v 7.2 +/- 1.2 cm3). Among the women with ADPKD, there was no correlation between mean ovarian volume and mean renal volume, nor was there a significant relationship between the occurrence of hepatic cystic disease and ovarian cysts. Therefore, a prospective imaging study suggests that ovarian cysts have no increased frequency in women with ADPKD compared with women in the general population. |
| معلومات مُعتمدة: | 5 PO1 DK34039 United States DK NIDDK NIH HHS |
| تواريخ الأحداث: | Date Created: 19990713 Date Completed: 19990726 Latest Revision: 20190815 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/s0272-6386(99)70117-4 |
| PMID: | 10401025 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1523-6838 |
|---|---|
| DOI: | 10.1016/s0272-6386(99)70117-4 |