دورية أكاديمية
أعرض في EDS

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.

التفاصيل البيبلوغرافية
العنوان: Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.
المؤلفون: Iritani BM; Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA. biritani@u.washington.edu, Alberola-Ila J, Forbush KA, Perimutter RM
المصدر: Immunity [Immunity] 1999 Jun; Vol. 10 (6), pp. 713-22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Print ISSN: 1074-7613 (Print) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1994-
مواضيع طبية MeSH: Alleles*, Lymphocyte Subsets/*immunology , Signal Transduction/*immunology , Stem Cells/*immunology, Alkyl and Aryl Transferases/biosynthesis ; Alkyl and Aryl Transferases/genetics ; Cell Differentiation/immunology ; DNA-Binding Proteins ; Enzyme Activation/immunology ; Gene Rearrangement, B-Lymphocyte, Heavy Chain/immunology ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/immunology ; Lymphocyte Subsets/metabolism ; Mitogen-Activated Protein Kinase Kinases ; Protein Kinases/metabolism ; Proto-Oncogene Proteins c-raf/biosynthesis ; Proto-Oncogene Proteins c-raf/genetics ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Signal Transduction/genetics ; Stem Cells/metabolism ; Transgenes/immunology
مستخلص: Successful in-frame rearrangement of immunoglobulin heavy chain genes or T cell antigen receptor (TCR) beta chain genes in lymphocyte progenitors results in formation of pre-BCR and pre-TCR complexes. These complexes signal progenitor cells to mature, expand in cell number, and suppress further rearrangements at the immunoglobulin heavy chain or TCRbeta chain loci, thereby ensuring allelic exclusion. We used transgenic expression of a constitutively active form of c-Raf-1 (Raf-CAAX) to demonstrate that activation of the Map kinase pathway can stimulate both maturation and expansion of B and T lymphocytes, even in the absence of pre-TCR or pre-BCR formation. However, the same Raf signal did not mediate allelic exclusion. We conclude that maturation of lymphocyte progenitors and allelic exclusion require distinct signals.
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معلومات مُعتمدة: K08 AI001445-06 United States AI NIAID NIH HHS; T32 RR007019 United States RR NCRR NIH HHS; 1 K08 AJ01445-01 United States PHS HHS; K08 AI001445-04 United States AI NIAID NIH HHS; T32 RR07019 United States RR NCRR NIH HHS; K08 AI001445-05 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (Recombinant Fusion Proteins)
0 (V(D)J recombination activating protein 2)
EC 2.5.- (Alkyl and Aryl Transferases)
EC 2.5.1.- (p21(ras) farnesyl-protein transferase)
EC 2.7.- (Protein Kinases)
EC 2.7.11.1 (Proto-Oncogene Proteins c-raf)
EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
تواريخ الأحداث: Date Created: 19990714 Date Completed: 19990720 Latest Revision: 20190915
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC5310940
DOI: 10.1016/s1074-7613(00)80070-9
PMID: 10403646
قاعدة البيانات: MEDLINE
الوصف
تدمد:1074-7613
DOI:10.1016/s1074-7613(00)80070-9