دورية أكاديمية
[Systemic palliative chemotherapy with 5-fluorouracil and leucovorin in disseminated colorectal cancer].
| العنوان: | [Systemic palliative chemotherapy with 5-fluorouracil and leucovorin in disseminated colorectal cancer]. |
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| عنوان ترانسليتريتد: | Systemisk pallierende kemoterapi med 5-fluorouracil og Leucovorin ved dissemineret kolorektal cancer. |
| المؤلفون: | Wiboltt K; Kirurgisk gastroenterologisk afdeling, Amtssygehuset i Gentofte., Raskov HH |
| المصدر: | Ugeskrift for laeger [Ugeskr Laeger] 1999 Jun 21; Vol. 161 (25), pp. 3827-32. |
| نوع المنشور: | Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial; Review |
| اللغة: | Danish |
| بيانات الدورية: | Publisher: Den Alm Danske Laegerforening Country of Publication: Denmark NLM ID: 0141730 Publication Model: Print Cited Medium: Print ISSN: 0041-5782 (Print) Linking ISSN: 00415782 NLM ISO Abbreviation: Ugeskr Laeger Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen : Den Alm Danske Laegerforening |
| مواضيع طبية MeSH: | Palliative Care*, Antimetabolites, Antineoplastic/*therapeutic use , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Colonic Neoplasms/*drug therapy , Fluorouracil/*therapeutic use , Leucovorin/*therapeutic use , Rectal Neoplasms/*drug therapy, Age Factors ; Aged ; Antimetabolites, Antineoplastic/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Colonic Neoplasms/mortality ; Colonic Neoplasms/psychology ; Fluorouracil/adverse effects ; Humans ; Leucovorin/adverse effects ; Meta-Analysis as Topic ; Quality of Life ; Randomized Controlled Trials as Topic ; Rectal Neoplasms/mortality ; Rectal Neoplasms/psychology |
| مستخلص: | Systemic palliative chemotherapy is usually regarded as ineffective in disseminated colorectal cancer, and the risk of toxic adverse effects is often considered a contraindication, as many patients are old and cannot be offered curative treatment. Randomized trials during the last decade have shown, however, that an effect on both survival and quality of life can be expected. Only casuistic reports of total remission have been published but a partial tumour response can be expected in 20-50% of patients. Toxicity is related to palliative chemotherapy and accelerated with old age (> 70 years). When disseminated colorectal cancer is diagnosed the possibility of palliative chemotherapy should be conferred with an oncologist. |
| Number of References: | 36 |
| المشرفين على المادة: | 0 (Antimetabolites, Antineoplastic) Q573I9DVLP (Leucovorin) U3P01618RT (Fluorouracil) |
| تواريخ الأحداث: | Date Created: 19990721 Date Completed: 19990727 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 10412300 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0041-5782 |
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